Trefoil factor 2 regulates airway remodeling in animal models of asthma

Simon Guy Royce, Clarice Lim, Ruth Cecilia Magdalene Muljadi, Mimi LK Tang

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

BACKGROUND: Epithelial denudation and metaplasia are important in the pathogenesis of airway remodeling and asthma. Trefoil factor 2 (TFF2) is a member of a family of peptides involved in protection and healing of the gastrointestinal epithelium but which are also secreted in the airway mucosa. METHODS: We investigated the role of TFF2 in airway remodeling by histological and morphometric analysis of lung tissue from TFF2-deficient mice subjected to two relevant animal models of asthma: an ovalbumin model of allergic airways disease and an Aspergillus fumigatus antigen sensitization model. RESULTS: In the ovalbumin model TFF2-deficient mice had increased goblet cell hyperplasia, but not epithelial thickening compared to wild-type (WT) counterparts. In the Aspergillus model TFF2-deficient mice also had increased goblet cell hyperplasia, and epithelial thickness was also increased in the Aspergillus-sensitized mice compared to WT controls. TFF2 deficiency was also associated with increased subepithelial collagen layer thickness. DISCUSSION: The current study demonstrates a role of TFF2 in airway remodeling in mouse models of airway disease. Further studies into the mechanisms of action of TFF2 and its role in asthma are warranted.
Original languageEnglish
Pages (from-to)653 - 659
Number of pages7
JournalJournal of Asthma
Volume48
Issue number7
DOIs
Publication statusPublished - 2011
Externally publishedYes

Cite this

Royce, Simon Guy ; Lim, Clarice ; Muljadi, Ruth Cecilia Magdalene ; Tang, Mimi LK. / Trefoil factor 2 regulates airway remodeling in animal models of asthma. In: Journal of Asthma. 2011 ; Vol. 48, No. 7. pp. 653 - 659.
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abstract = "BACKGROUND: Epithelial denudation and metaplasia are important in the pathogenesis of airway remodeling and asthma. Trefoil factor 2 (TFF2) is a member of a family of peptides involved in protection and healing of the gastrointestinal epithelium but which are also secreted in the airway mucosa. METHODS: We investigated the role of TFF2 in airway remodeling by histological and morphometric analysis of lung tissue from TFF2-deficient mice subjected to two relevant animal models of asthma: an ovalbumin model of allergic airways disease and an Aspergillus fumigatus antigen sensitization model. RESULTS: In the ovalbumin model TFF2-deficient mice had increased goblet cell hyperplasia, but not epithelial thickening compared to wild-type (WT) counterparts. In the Aspergillus model TFF2-deficient mice also had increased goblet cell hyperplasia, and epithelial thickness was also increased in the Aspergillus-sensitized mice compared to WT controls. TFF2 deficiency was also associated with increased subepithelial collagen layer thickness. DISCUSSION: The current study demonstrates a role of TFF2 in airway remodeling in mouse models of airway disease. Further studies into the mechanisms of action of TFF2 and its role in asthma are warranted.",
author = "Royce, {Simon Guy} and Clarice Lim and Muljadi, {Ruth Cecilia Magdalene} and Tang, {Mimi LK}",
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Trefoil factor 2 regulates airway remodeling in animal models of asthma. / Royce, Simon Guy; Lim, Clarice; Muljadi, Ruth Cecilia Magdalene; Tang, Mimi LK.

In: Journal of Asthma, Vol. 48, No. 7, 2011, p. 653 - 659.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Trefoil factor 2 regulates airway remodeling in animal models of asthma

AU - Royce, Simon Guy

AU - Lim, Clarice

AU - Muljadi, Ruth Cecilia Magdalene

AU - Tang, Mimi LK

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N2 - BACKGROUND: Epithelial denudation and metaplasia are important in the pathogenesis of airway remodeling and asthma. Trefoil factor 2 (TFF2) is a member of a family of peptides involved in protection and healing of the gastrointestinal epithelium but which are also secreted in the airway mucosa. METHODS: We investigated the role of TFF2 in airway remodeling by histological and morphometric analysis of lung tissue from TFF2-deficient mice subjected to two relevant animal models of asthma: an ovalbumin model of allergic airways disease and an Aspergillus fumigatus antigen sensitization model. RESULTS: In the ovalbumin model TFF2-deficient mice had increased goblet cell hyperplasia, but not epithelial thickening compared to wild-type (WT) counterparts. In the Aspergillus model TFF2-deficient mice also had increased goblet cell hyperplasia, and epithelial thickness was also increased in the Aspergillus-sensitized mice compared to WT controls. TFF2 deficiency was also associated with increased subepithelial collagen layer thickness. DISCUSSION: The current study demonstrates a role of TFF2 in airway remodeling in mouse models of airway disease. Further studies into the mechanisms of action of TFF2 and its role in asthma are warranted.

AB - BACKGROUND: Epithelial denudation and metaplasia are important in the pathogenesis of airway remodeling and asthma. Trefoil factor 2 (TFF2) is a member of a family of peptides involved in protection and healing of the gastrointestinal epithelium but which are also secreted in the airway mucosa. METHODS: We investigated the role of TFF2 in airway remodeling by histological and morphometric analysis of lung tissue from TFF2-deficient mice subjected to two relevant animal models of asthma: an ovalbumin model of allergic airways disease and an Aspergillus fumigatus antigen sensitization model. RESULTS: In the ovalbumin model TFF2-deficient mice had increased goblet cell hyperplasia, but not epithelial thickening compared to wild-type (WT) counterparts. In the Aspergillus model TFF2-deficient mice also had increased goblet cell hyperplasia, and epithelial thickness was also increased in the Aspergillus-sensitized mice compared to WT controls. TFF2 deficiency was also associated with increased subepithelial collagen layer thickness. DISCUSSION: The current study demonstrates a role of TFF2 in airway remodeling in mouse models of airway disease. Further studies into the mechanisms of action of TFF2 and its role in asthma are warranted.

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