Treatment, therapy and management of metabolic epilepsy: A systematic review

Vanessa Lin Lin Lee, Brandon Kar Meng Choo, Yin Sir Chung, Uday P. Kundap, Yatinesh Kumari, Mohd Farooq Shaikh

    Research output: Contribution to journalReview ArticleResearchpeer-review

    11 Citations (Scopus)

    Abstract

    Metabolic epilepsy is a metabolic abnormality which is associated with an increased risk of epilepsy development in affected individuals. Commonly used antiepileptic drugs are typically ineffective against metabolic epilepsy as they do not address its root cause. Presently, there is no review available which summarizes all the treatment options for metabolic epilepsy. Thus, we systematically reviewed literature which reported on the treatment, therapy and management of metabolic epilepsy from four databases, namely PubMed, Springer, Scopus and Science Direct. After applying our inclusion and exclusion criteria as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed a total of 43 articles. Based on the reviewed articles, we summarized the methods used for the treatment, therapy and management of metabolic epilepsy. These methods were tailored to address the root causes of the metabolic disturbances rather than targeting the epilepsy phenotype alone. Diet modification and dietary supplementation, alone or in combination with antiepileptic drugs, are used in tackling the different types of metabolic epilepsy. Identification, treatment, therapy and management of the underlying metabolic derangements can improve behavior, cognitive function and reduce seizure frequency and/or severity in patients.

    Original languageEnglish
    Article number871
    Number of pages20
    JournalInternational Journal of Molecular Sciences
    Volume19
    Issue number3
    DOIs
    Publication statusPublished - 15 Mar 2018

    Keywords

    • Antiepileptic drugs
    • Cognitive function
    • Dietary therapy
    • Metabolic disorders
    • Metabolic epilepsy
    • Seizures

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