Treatment, therapy and management of metabolic epilepsy: A systematic review

Vanessa Lin Lin Lee, Brandon Kar Meng Choo, Yin Sir Chung, Uday P. Kundap, Yatinesh Kumari, Mohd Farooq Shaikh

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)


Metabolic epilepsy is a metabolic abnormality which is associated with an increased risk of epilepsy development in affected individuals. Commonly used antiepileptic drugs are typically ineffective against metabolic epilepsy as they do not address its root cause. Presently, there is no review available which summarizes all the treatment options for metabolic epilepsy. Thus, we systematically reviewed literature which reported on the treatment, therapy and management of metabolic epilepsy from four databases, namely PubMed, Springer, Scopus and Science Direct. After applying our inclusion and exclusion criteria as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed a total of 43 articles. Based on the reviewed articles, we summarized the methods used for the treatment, therapy and management of metabolic epilepsy. These methods were tailored to address the root causes of the metabolic disturbances rather than targeting the epilepsy phenotype alone. Diet modification and dietary supplementation, alone or in combination with antiepileptic drugs, are used in tackling the different types of metabolic epilepsy. Identification, treatment, therapy and management of the underlying metabolic derangements can improve behavior, cognitive function and reduce seizure frequency and/or severity in patients.

Original languageEnglish
Article number871
Number of pages20
JournalInternational Journal of Molecular Sciences
Issue number3
Publication statusPublished - 15 Mar 2018


  • Antiepileptic drugs
  • Cognitive function
  • Dietary therapy
  • Metabolic disorders
  • Metabolic epilepsy
  • Seizures

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