Treatment selection for first-line metastatic renal cell carcinoma in Australia: Impact of new therapy options

Andrew Schmidt, Arun Azad, Jeffrey Goh, Carole Harris, Anthony M. Joshua, Andrew Weickhardt, Laurence Krieger

Research output: Contribution to journalArticleResearchpeer-review


Vascular endothelial growth factor receptor tyrosine kinase inhibitors have provided an effective standard of care for the treatment of metastatic clear cell renal cell carcinoma (mRCC). Survival is prolonged with emergence of modern immuno-oncology combination regimens. Prognostic risk assessment is essential for choosing between these therapies to determine the most appropriate first line treatment option, with selection based on International Metastatic RCC Database Consortium Risk Category. We review the current subsidized first line treatments for mRCC in Australia and consider the evidence for treatment selection and sequencing.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalAsia-Pacific Journal of Clinical Oncology
Issue numberS10
Publication statusPublished - Nov 2019
Externally publishedYes


  • immuno-oncology
  • renal cell carcinoma
  • VEGF tyrosine kinase inhibitors

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