Treatment outcomes of alginate-embedded allogenic mesenchymal stem cells versus autologous chrondrocytes for the repair of focal articular cartilage defects in a rabbit model

Liang Xin Tay; Raja Elina Ahmad; Havva Dashtdar; K W Tay; T Masjuddin; S Ab-Rahim; Pan Pan Chong; Lakshmi Selvaratnam; Tunku Kamarul

doi:10.1177/0363546511420819

Treatment outcomes of alginate-embedded allogenic mesenchymal stem cells versus autologous chrondrocytes for the repair of focal articular cartilage defects in a rabbit model

Liang Xin Tay, Raja Elina Ahmad, Havva Dashtdar, K W Tay, T Masjuddin, S Ab-Rahim, Pan Pan Chong, Lakshmi Selvaratnam, Tunku Kamarul

Malaysia Jeffrey Cheah Sch of Med & HS

Research output: Contribution to journal › Article › Research › peer-review

82 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) represent a promising alternative form of cell-based therapy for cartilage injury. However, the capacity of MSCs for chondrogenesis has not been fully explored. In particular, there is presently a lack of studies comparing the effectiveness of MSCs to conventional autologous chondrocyte (autoC) treatment for regeneration of full-thickness cartilage defects in vivo.

Original language	English
Pages (from-to)	83 - 90
Number of pages	8
Journal	The American Journal of Sports Medicine
Volume	4
Issue number	1
DOIs	https://doi.org/10.1177/0363546511420819
Publication status	Published - 2012

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Tay, L. X., Ahmad, R. E., Dashtdar, H., Tay, K. W., Masjuddin, T., Ab-Rahim, S., Chong, P. P., Selvaratnam, L., & Kamarul, T. (2012). Treatment outcomes of alginate-embedded allogenic mesenchymal stem cells versus autologous chrondrocytes for the repair of focal articular cartilage defects in a rabbit model. The American Journal of Sports Medicine, 4(1), 83 - 90. https://doi.org/10.1177/0363546511420819

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abstract = "Mesenchymal stem cells (MSCs) represent a promising alternative form of cell-based therapy for cartilage injury. However, the capacity of MSCs for chondrogenesis has not been fully explored. In particular, there is presently a lack of studies comparing the effectiveness of MSCs to conventional autologous chondrocyte (autoC) treatment for regeneration of full-thickness cartilage defects in vivo.",

author = "Tay, {Liang Xin} and Ahmad, {Raja Elina} and Havva Dashtdar and Tay, {K W} and T Masjuddin and S Ab-Rahim and Chong, {Pan Pan} and Lakshmi Selvaratnam and Tunku Kamarul",

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Tay, LX, Ahmad, RE, Dashtdar, H, Tay, KW, Masjuddin, T, Ab-Rahim, S, Chong, PP, Selvaratnam, L & Kamarul, T 2012, 'Treatment outcomes of alginate-embedded allogenic mesenchymal stem cells versus autologous chrondrocytes for the repair of focal articular cartilage defects in a rabbit model', The American Journal of Sports Medicine, vol. 4, no. 1, pp. 83 - 90. https://doi.org/10.1177/0363546511420819

Treatment outcomes of alginate-embedded allogenic mesenchymal stem cells versus autologous chrondrocytes for the repair of focal articular cartilage defects in a rabbit model. / Tay, Liang Xin; Ahmad, Raja Elina; Dashtdar, Havva et al.
In: The American Journal of Sports Medicine, Vol. 4, No. 1, 2012, p. 83 - 90.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Masjuddin, T

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AB - Mesenchymal stem cells (MSCs) represent a promising alternative form of cell-based therapy for cartilage injury. However, the capacity of MSCs for chondrogenesis has not been fully explored. In particular, there is presently a lack of studies comparing the effectiveness of MSCs to conventional autologous chondrocyte (autoC) treatment for regeneration of full-thickness cartilage defects in vivo.

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Treatment outcomes of alginate-embedded allogenic mesenchymal stem cells versus autologous chrondrocytes for the repair of focal articular cartilage defects in a rabbit model

Abstract

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