Treatment of resistant intracranial hypertension with hypertonic saline. Report of two cases

L. I.G. Worthley, D. J. Cooper, N. Jones

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The authors describe two patients with traumatic cerebral edema and intracranial hypertension in whom the continued use of mannitol and furosemide resulted in a progressive lessening of the effect of these agents on the intracranial pressure (ICP) and caused prerenal failure. Intravenous administration of hypertonic saline (50 ml and 20 ml of a 5-mmol/ml saline solution over 10 minutes in Cases 1 and 2, respectively) produced a prolonged reduction in the ICP and improved renal function in both cases. It is suggested that if a reduction in ICP without diuresis is required in patients with traumatic cerebral edema, treatment with intravenous hypertonic saline should be considered.

Original languageEnglish
Pages (from-to)478-481
Number of pages4
JournalJournal of Neurosurgery
Issue number3
Publication statusPublished - 1 Jan 1988

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