Treatment of hepatitis B e antigen-positive chronic hepatitis with telbivudine or adefovir: A randomized trial

Henry L Y Chan, J Heathcote, Patrick Marcellin, Ching-Lung Lung Lai, Mong Cho, Young S Moon, You-Chen Chao, Robert P Myers, Gerald Y Minuk, Lennox Jeffers, William Sievert, Natalie Bzowej, George Harb, Ralf Kaiser, Xin-Jian Qiao, Nathaniel A Brown

Research output: Contribution to journalArticleResearchpeer-review

181 Citations (Scopus)


Background: The efficacy of nucleoside and nucleotide analogues for hepatitis B has been linked to the magnitude and durability of hepatitis B virus (HBV) suppression. Objective: To compare the antiviral efficacy of telbivudine and adefovir dipivoxil, and the effects of switching from adefovir to telbivudine, in hepatitis B e antigen (HBeAg)a??positive patients with chronic hepatitis B.
Original languageEnglish
Pages (from-to)745 - 754
Number of pages10
JournalAnnals of Internal Medicine
Issue number11
Publication statusPublished - 2007

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