Treatable traits

A new paradigm for 21st century management of chronic airway diseases: Treatable Traits down under International Workshop report

Vanessa M. McDonald, James Fingleton, Alvar Agusti, Sarah A. Hiles, Vanessa L. Clark, Anne E. Holland, Guy B. Marks, Philip P. Bardin, Richard Beasley, Ian D. Pavord, Peter A.B. Wark, Peter G. Gibson, on behalf of the participants of the Treatable Traits Down Under International Workshop

Research output: Contribution to journalReview ArticleOtherpeer-review

8 Citations (Scopus)

Abstract

“Treatable traits” have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches from concepts to practice is challenging, but necessary. In an effort to accelerate progress in research and practice relating to the treatable traits approach, the Treatable Traits Down Under International Workshop was convened in Melbourne, Australia in May 2018. Here, we report the key concepts and research questions that emerged in discussions during the meeting. We propose a programme of research that involves gaining international consensus on candidate traits, recognising the prevalence of traits, and identifying a potential hierarchy of traits based on their clinical impact and responsiveness to treatment. We also reflect on research methods and designs that can generate new knowledge related to efficacy of the treatable traits approach and consider multidisciplinary models of care that may aid its implementation into practice.

Original languageEnglish
Article number1802058
Number of pages16
JournalEuropean Respiratory Journal
Volume53
Issue number5
DOIs
Publication statusPublished - 2019

Cite this

McDonald, V. M., Fingleton, J., Agusti, A., Hiles, S. A., Clark, V. L., Holland, A. E., ... on behalf of the participants of the Treatable Traits Down Under International Workshop (2019). Treatable traits: A new paradigm for 21st century management of chronic airway diseases: Treatable Traits down under International Workshop report. European Respiratory Journal, 53(5), [1802058]. https://doi.org/10.1183/13993003.02058-2018
McDonald, Vanessa M. ; Fingleton, James ; Agusti, Alvar ; Hiles, Sarah A. ; Clark, Vanessa L. ; Holland, Anne E. ; Marks, Guy B. ; Bardin, Philip P. ; Beasley, Richard ; Pavord, Ian D. ; Wark, Peter A.B. ; Gibson, Peter G. ; on behalf of the participants of the Treatable Traits Down Under International Workshop. / Treatable traits : A new paradigm for 21st century management of chronic airway diseases: Treatable Traits down under International Workshop report. In: European Respiratory Journal. 2019 ; Vol. 53, No. 5.
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abstract = "“Treatable traits” have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches from concepts to practice is challenging, but necessary. In an effort to accelerate progress in research and practice relating to the treatable traits approach, the Treatable Traits Down Under International Workshop was convened in Melbourne, Australia in May 2018. Here, we report the key concepts and research questions that emerged in discussions during the meeting. We propose a programme of research that involves gaining international consensus on candidate traits, recognising the prevalence of traits, and identifying a potential hierarchy of traits based on their clinical impact and responsiveness to treatment. We also reflect on research methods and designs that can generate new knowledge related to efficacy of the treatable traits approach and consider multidisciplinary models of care that may aid its implementation into practice.",
author = "McDonald, {Vanessa M.} and James Fingleton and Alvar Agusti and Hiles, {Sarah A.} and Clark, {Vanessa L.} and Holland, {Anne E.} and Marks, {Guy B.} and Bardin, {Philip P.} and Richard Beasley and Pavord, {Ian D.} and Wark, {Peter A.B.} and Gibson, {Peter G.} and {on behalf of the participants of the Treatable Traits Down Under International Workshop}",
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McDonald, VM, Fingleton, J, Agusti, A, Hiles, SA, Clark, VL, Holland, AE, Marks, GB, Bardin, PP, Beasley, R, Pavord, ID, Wark, PAB, Gibson, PG & on behalf of the participants of the Treatable Traits Down Under International Workshop 2019, 'Treatable traits: A new paradigm for 21st century management of chronic airway diseases: Treatable Traits down under International Workshop report', European Respiratory Journal, vol. 53, no. 5, 1802058. https://doi.org/10.1183/13993003.02058-2018

Treatable traits : A new paradigm for 21st century management of chronic airway diseases: Treatable Traits down under International Workshop report. / McDonald, Vanessa M.; Fingleton, James; Agusti, Alvar; Hiles, Sarah A.; Clark, Vanessa L.; Holland, Anne E.; Marks, Guy B.; Bardin, Philip P.; Beasley, Richard; Pavord, Ian D.; Wark, Peter A.B.; Gibson, Peter G.; on behalf of the participants of the Treatable Traits Down Under International Workshop.

In: European Respiratory Journal, Vol. 53, No. 5, 1802058, 2019.

Research output: Contribution to journalReview ArticleOtherpeer-review

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AU - Fingleton, James

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AU - Holland, Anne E.

AU - Marks, Guy B.

AU - Bardin, Philip P.

AU - Beasley, Richard

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AU - Wark, Peter A.B.

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