Traumatic brain injury induces elevation of Co in the human brain

Blaine R Roberts, Dominic J Hare, Catriona A McLean, Alison Conquest, Monica Lind, Qiao-Xin Li, Ashley I Bush, Colin L Masters, Maria-Cristina Morganti-Kossmann, Tony J Frugier

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is the most common cause of death and disability in young adults, yet the molecular mechanisms that follow TBI are poorly understood. We previously reported a perturbation in iron (Fe) levels following TBI. Here we report that the distribution of cobalt (Co) is modulated in post-mortem human brain following injury. We also investigated how the distribution of other biologically relevant elements changes in TBI. Cobalt is increased due to TBI while copper (Cu), magnesium (Mg), manganese (Mn), phosphorus (P), potassium (K), rubidium (Rb), selenium (Se) and zinc (Zn) remain unchanged. The elevated Co has important implications for positron emission tomography neuroimaging. This is the first demonstration of the accumulation of Co in injured tissue explaining the previous utility of 55Co-PET imaging in TBI.
Original languageEnglish
Pages (from-to)66-70
Number of pages5
JournalMetallomics
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Cite this

Roberts, B. R., Hare, D. J., McLean, C. A., Conquest, A., Lind, M., Li, Q-X., ... Frugier, T. J. (2015). Traumatic brain injury induces elevation of Co in the human brain. Metallomics, 7(1), 66-70. https://doi.org/10.1039/C4MT00258J
Roberts, Blaine R ; Hare, Dominic J ; McLean, Catriona A ; Conquest, Alison ; Lind, Monica ; Li, Qiao-Xin ; Bush, Ashley I ; Masters, Colin L ; Morganti-Kossmann, Maria-Cristina ; Frugier, Tony J. / Traumatic brain injury induces elevation of Co in the human brain. In: Metallomics. 2015 ; Vol. 7, No. 1. pp. 66-70.
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Roberts, BR, Hare, DJ, McLean, CA, Conquest, A, Lind, M, Li, Q-X, Bush, AI, Masters, CL, Morganti-Kossmann, M-C & Frugier, TJ 2015, 'Traumatic brain injury induces elevation of Co in the human brain', Metallomics, vol. 7, no. 1, pp. 66-70. https://doi.org/10.1039/C4MT00258J

Traumatic brain injury induces elevation of Co in the human brain. / Roberts, Blaine R; Hare, Dominic J; McLean, Catriona A; Conquest, Alison; Lind, Monica; Li, Qiao-Xin; Bush, Ashley I; Masters, Colin L; Morganti-Kossmann, Maria-Cristina; Frugier, Tony J.

In: Metallomics, Vol. 7, No. 1, 01.01.2015, p. 66-70.

Research output: Contribution to journalArticleResearchpeer-review

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Roberts BR, Hare DJ, McLean CA, Conquest A, Lind M, Li Q-X et al. Traumatic brain injury induces elevation of Co in the human brain. Metallomics. 2015 Jan 1;7(1):66-70. https://doi.org/10.1039/C4MT00258J