Transport and deposition of cohesive pharmaceutical powders in human airway

Yuan Wang, Kaiwei Chu, Aibing Yu

Research output: Contribution to journalConference articleOther

Abstract

Pharmaceutical powders used in inhalation therapy are in the size range of 1-5 microns and are usually cohesive. Understanding the cohesive behaviour of pharmaceutical powders during their transportation in human airway is significant in optimising aerosol drug delivery and targeting. In this study, the transport and deposition of cohesive pharmaceutical powders in a human airway model is simulated by a well-established numerical model which combines computational fluid dynamics (CFD) and discrete element method (DEM). The van der Waals force, as the dominant cohesive force, is simulated and its influence on particle transport and deposition behaviour is discussed. It is observed that even for dilute particle flow, the local particle concentration in the oral to trachea region can be high and particle aggregation happens due to the van der Waals force of attraction. It is concluded that the deposition mechanism for cohesive pharmaceutical powders, on one hand, is dominated by particle inertial impaction, as proven by previous studies; on the other hand, is significantly affected by particle aggregation induced by van der Waals force. To maximum respiratory drug delivery efficiency, efforts should be made to avoid pharmaceutical powder aggregation in human oral-to-trachea airway.

Original languageEnglish
Article number08004
Number of pages4
JournalEPJ Web of Conferences
Volume140
DOIs
Publication statusPublished - 30 Jun 2017
EventPowders and Grains 2017 - Montpellier, France
Duration: 3 Jul 20177 Jul 2017
Conference number: 8th
http://pg2017.org/en/

Cite this

@article{e4cb0a0f895e4a19a9e936bc282ca417,
title = "Transport and deposition of cohesive pharmaceutical powders in human airway",
abstract = "Pharmaceutical powders used in inhalation therapy are in the size range of 1-5 microns and are usually cohesive. Understanding the cohesive behaviour of pharmaceutical powders during their transportation in human airway is significant in optimising aerosol drug delivery and targeting. In this study, the transport and deposition of cohesive pharmaceutical powders in a human airway model is simulated by a well-established numerical model which combines computational fluid dynamics (CFD) and discrete element method (DEM). The van der Waals force, as the dominant cohesive force, is simulated and its influence on particle transport and deposition behaviour is discussed. It is observed that even for dilute particle flow, the local particle concentration in the oral to trachea region can be high and particle aggregation happens due to the van der Waals force of attraction. It is concluded that the deposition mechanism for cohesive pharmaceutical powders, on one hand, is dominated by particle inertial impaction, as proven by previous studies; on the other hand, is significantly affected by particle aggregation induced by van der Waals force. To maximum respiratory drug delivery efficiency, efforts should be made to avoid pharmaceutical powder aggregation in human oral-to-trachea airway.",
author = "Yuan Wang and Kaiwei Chu and Aibing Yu",
year = "2017",
month = "6",
day = "30",
doi = "10.1051/epjconf/201714008004",
language = "English",
volume = "140",
journal = "EPJ Web of Conferences",
issn = "2100-014X",
publisher = "EDP Sciences",

}

Transport and deposition of cohesive pharmaceutical powders in human airway. / Wang, Yuan; Chu, Kaiwei; Yu, Aibing.

In: EPJ Web of Conferences, Vol. 140, 08004, 30.06.2017.

Research output: Contribution to journalConference articleOther

TY - JOUR

T1 - Transport and deposition of cohesive pharmaceutical powders in human airway

AU - Wang, Yuan

AU - Chu, Kaiwei

AU - Yu, Aibing

PY - 2017/6/30

Y1 - 2017/6/30

N2 - Pharmaceutical powders used in inhalation therapy are in the size range of 1-5 microns and are usually cohesive. Understanding the cohesive behaviour of pharmaceutical powders during their transportation in human airway is significant in optimising aerosol drug delivery and targeting. In this study, the transport and deposition of cohesive pharmaceutical powders in a human airway model is simulated by a well-established numerical model which combines computational fluid dynamics (CFD) and discrete element method (DEM). The van der Waals force, as the dominant cohesive force, is simulated and its influence on particle transport and deposition behaviour is discussed. It is observed that even for dilute particle flow, the local particle concentration in the oral to trachea region can be high and particle aggregation happens due to the van der Waals force of attraction. It is concluded that the deposition mechanism for cohesive pharmaceutical powders, on one hand, is dominated by particle inertial impaction, as proven by previous studies; on the other hand, is significantly affected by particle aggregation induced by van der Waals force. To maximum respiratory drug delivery efficiency, efforts should be made to avoid pharmaceutical powder aggregation in human oral-to-trachea airway.

AB - Pharmaceutical powders used in inhalation therapy are in the size range of 1-5 microns and are usually cohesive. Understanding the cohesive behaviour of pharmaceutical powders during their transportation in human airway is significant in optimising aerosol drug delivery and targeting. In this study, the transport and deposition of cohesive pharmaceutical powders in a human airway model is simulated by a well-established numerical model which combines computational fluid dynamics (CFD) and discrete element method (DEM). The van der Waals force, as the dominant cohesive force, is simulated and its influence on particle transport and deposition behaviour is discussed. It is observed that even for dilute particle flow, the local particle concentration in the oral to trachea region can be high and particle aggregation happens due to the van der Waals force of attraction. It is concluded that the deposition mechanism for cohesive pharmaceutical powders, on one hand, is dominated by particle inertial impaction, as proven by previous studies; on the other hand, is significantly affected by particle aggregation induced by van der Waals force. To maximum respiratory drug delivery efficiency, efforts should be made to avoid pharmaceutical powder aggregation in human oral-to-trachea airway.

UR - http://www.scopus.com/inward/record.url?scp=85024104318&partnerID=8YFLogxK

U2 - 10.1051/epjconf/201714008004

DO - 10.1051/epjconf/201714008004

M3 - Conference article

VL - 140

JO - EPJ Web of Conferences

JF - EPJ Web of Conferences

SN - 2100-014X

M1 - 08004

ER -