Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl 4-treated mice

Ursula Manuelpillai, Jorge Tchongue, Dinuska Dowling, Vijesh Vaghjiani, Chrishan Samuel, Alison Liu, Elizabeth Williams, William Sievert

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141 Citations (Scopus)

Abstract

Chronic liver injury and inflammation lead to hepatic fibrosis, cirrhosis, and liver failure. Embryonic and mesenchymal stem cells have been shown to reduce experimental liver fibrosis but have potential limitations, including the formation of dysplastic precursors, tumors, and profibrogenic cells. Other stem-like cells may reduce hepatic inflammation and fibrosis without tumor and profibrogenic cell formation. To test this hypothesis we transplanted human amnion epithelial cells (hAEC), isolated from term delivered placenta, into immunocompetent C57/BL6 mice at week 2 of a 4-week regimen of carbon tetrachloride (CCl4-) exposure to induce liver fibrosis.
Original languageEnglish
Pages (from-to)1157 - 1168
Number of pages12
JournalCell Transplantation
Volume19
Issue number9
DOIs
Publication statusPublished - 2010

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