Transperineal vs. transrectal biopsy in MRI targeting

Jeremy Grummet, Lana Pepdjonovic, Sean Huang, Elliot Anderson, Boris Hadaschik

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Prostate biopsy is typically performed via either the transrectal or transperineal approach. MRItargeted biopsy, whether using any of the three options of cognitive fusion, MRI-ultrasound fusion software, or in-bore MRI-guided biopsy, can also be performed via either transrectal or transperineal approaches. As an extension of traditional random prostate biopsy, the transrectal approach is far more commonly used for MRI-targeted biopsy due to its convenience. However, in the context of today's increasing multidrug resistance of rectal flora, the transperineal approach is being used more often due to its lack of septic complications. In addition, only a first-generation cephalosporin, not a fluoroquinolone, is required as antibiotic prophylaxis. Evidence shows excellent detection rates of significant prostate cancer using magnetic resonance imaging (MRI)-targeted and/or systematic transperineal biopsy (TPB). However, there are no head-to-head studies comparing the different MRI-targeted methods within TPB. To provide truly patientcentred care, the biopsy technique using the safest method with the highest detection rate of significant cancer should be used. Depending on healthcare context and hospital resource utilization, MRI-targeted TPB is an excellent option and should be performed wherever available and feasible. Whilst building capacity for TPB in one's practice, the routine use of rectal culture swabs prior to any transrectal biopsies is strongly encouraged. Independent of biopsy route, the addition of systematic cores needs to be discussed with the patient weighing maximal detection of significant cancer against increased detection of insignificant lesions.

Original languageEnglish
Pages (from-to)368-375
Number of pages8
JournalTranslational Andrology and Urology
Volume6
Issue number3
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Bacterial
  • Drug-resistance
  • Image-guided biopsy
  • Magnetic resonance imaging (MRI)
  • Prostatic neoplasms

Cite this

Grummet, Jeremy ; Pepdjonovic, Lana ; Huang, Sean ; Anderson, Elliot ; Hadaschik, Boris. / Transperineal vs. transrectal biopsy in MRI targeting. In: Translational Andrology and Urology. 2017 ; Vol. 6, No. 3. pp. 368-375.
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Grummet, J, Pepdjonovic, L, Huang, S, Anderson, E & Hadaschik, B 2017, 'Transperineal vs. transrectal biopsy in MRI targeting', Translational Andrology and Urology, vol. 6, no. 3, pp. 368-375. https://doi.org/10.21037/tau.2017.03.58

Transperineal vs. transrectal biopsy in MRI targeting. / Grummet, Jeremy; Pepdjonovic, Lana; Huang, Sean; Anderson, Elliot; Hadaschik, Boris.

In: Translational Andrology and Urology, Vol. 6, No. 3, 01.06.2017, p. 368-375.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Transperineal vs. transrectal biopsy in MRI targeting

AU - Grummet, Jeremy

AU - Pepdjonovic, Lana

AU - Huang, Sean

AU - Anderson, Elliot

AU - Hadaschik, Boris

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Prostate biopsy is typically performed via either the transrectal or transperineal approach. MRItargeted biopsy, whether using any of the three options of cognitive fusion, MRI-ultrasound fusion software, or in-bore MRI-guided biopsy, can also be performed via either transrectal or transperineal approaches. As an extension of traditional random prostate biopsy, the transrectal approach is far more commonly used for MRI-targeted biopsy due to its convenience. However, in the context of today's increasing multidrug resistance of rectal flora, the transperineal approach is being used more often due to its lack of septic complications. In addition, only a first-generation cephalosporin, not a fluoroquinolone, is required as antibiotic prophylaxis. Evidence shows excellent detection rates of significant prostate cancer using magnetic resonance imaging (MRI)-targeted and/or systematic transperineal biopsy (TPB). However, there are no head-to-head studies comparing the different MRI-targeted methods within TPB. To provide truly patientcentred care, the biopsy technique using the safest method with the highest detection rate of significant cancer should be used. Depending on healthcare context and hospital resource utilization, MRI-targeted TPB is an excellent option and should be performed wherever available and feasible. Whilst building capacity for TPB in one's practice, the routine use of rectal culture swabs prior to any transrectal biopsies is strongly encouraged. Independent of biopsy route, the addition of systematic cores needs to be discussed with the patient weighing maximal detection of significant cancer against increased detection of insignificant lesions.

AB - Prostate biopsy is typically performed via either the transrectal or transperineal approach. MRItargeted biopsy, whether using any of the three options of cognitive fusion, MRI-ultrasound fusion software, or in-bore MRI-guided biopsy, can also be performed via either transrectal or transperineal approaches. As an extension of traditional random prostate biopsy, the transrectal approach is far more commonly used for MRI-targeted biopsy due to its convenience. However, in the context of today's increasing multidrug resistance of rectal flora, the transperineal approach is being used more often due to its lack of septic complications. In addition, only a first-generation cephalosporin, not a fluoroquinolone, is required as antibiotic prophylaxis. Evidence shows excellent detection rates of significant prostate cancer using magnetic resonance imaging (MRI)-targeted and/or systematic transperineal biopsy (TPB). However, there are no head-to-head studies comparing the different MRI-targeted methods within TPB. To provide truly patientcentred care, the biopsy technique using the safest method with the highest detection rate of significant cancer should be used. Depending on healthcare context and hospital resource utilization, MRI-targeted TPB is an excellent option and should be performed wherever available and feasible. Whilst building capacity for TPB in one's practice, the routine use of rectal culture swabs prior to any transrectal biopsies is strongly encouraged. Independent of biopsy route, the addition of systematic cores needs to be discussed with the patient weighing maximal detection of significant cancer against increased detection of insignificant lesions.

KW - Bacterial

KW - Drug-resistance

KW - Image-guided biopsy

KW - Magnetic resonance imaging (MRI)

KW - Prostatic neoplasms

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DO - 10.21037/tau.2017.03.58

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JF - Translational Andrology and Urology

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ER -