Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia

Praphan Phanuphak; Sunee Sirivichayakul; Awachana Jiamsakul; Somnuek Sungkanuparph; Nagalingeswaran Kumarasamy; Man Po Lee; Thira Sirisanthana; Pacharee Kantipong; Christopher Lee; Adeeba Kamarulzaman; Mahiran Mustafa; Rossana Ditangco; Tuti Merati; Winai Ratanasuwan; Thida Singtoroj; Rami Kantor

doi:10.1097/QAI.0000000000000108

Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia

Praphan Phanuphak
, Sunee Sirivichayakul
, Awachana Jiamsakul
, Somnuek Sungkanuparph
, Nagalingeswaran Kumarasamy
, Man Po Lee
, Thira Sirisanthana
, Pacharee Kantipong
, Christopher Lee
, Adeeba Kamarulzaman
, Mahiran Mustafa
, Rossana Ditangco
, Tuti Merati
, Winai Ratanasuwan
, Thida Singtoroj
, Rami Kantor

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

Original language	English
Pages (from-to)	74-79
Number of pages	6
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	66
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0000000000000108
Publication status	Published - 1 May 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ART outcome
HIV-1
South East Asia
transmitted drug resistance

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10.1097/QAI.0000000000000108

Cite this

Phanuphak, P., Sirivichayakul, S., Jiamsakul, A., Sungkanuparph, S., Kumarasamy, N., Lee, M. P., Sirisanthana, T., Kantipong, P., Lee, C., Kamarulzaman, A., Mustafa, M., Ditangco, R., Merati, T., Ratanasuwan, W., Singtoroj, T., & Kantor, R. (2014). Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia. Journal of Acquired Immune Deficiency Syndromes, 66(1), 74-79. https://doi.org/10.1097/QAI.0000000000000108

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title = "Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia",

abstract = "BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1\%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.",

keywords = "ART outcome, HIV-1, South East Asia, transmitted drug resistance",

author = "Praphan Phanuphak and Sunee Sirivichayakul and Awachana Jiamsakul and Somnuek Sungkanuparph and Nagalingeswaran Kumarasamy and Lee, \{Man Po\} and Thira Sirisanthana and Pacharee Kantipong and Christopher Lee and Adeeba Kamarulzaman and Mahiran Mustafa and Rossana Ditangco and Tuti Merati and Winai Ratanasuwan and Thida Singtoroj and Rami Kantor",

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doi = "10.1097/QAI.0000000000000108",

language = "English",

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Phanuphak, P, Sirivichayakul, S, Jiamsakul, A, Sungkanuparph, S, Kumarasamy, N, Lee, MP, Sirisanthana, T, Kantipong, P, Lee, C, Kamarulzaman, A, Mustafa, M, Ditangco, R, Merati, T, Ratanasuwan, W, Singtoroj, T & Kantor, R 2014, 'Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia', Journal of Acquired Immune Deficiency Syndromes, vol. 66, no. 1, pp. 74-79. https://doi.org/10.1097/QAI.0000000000000108

Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia. / Phanuphak, Praphan; Sirivichayakul, Sunee; Jiamsakul, Awachana et al.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 66, No. 1, 01.05.2014, p. 74-79.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia

AU - Phanuphak, Praphan

AU - Sirivichayakul, Sunee

AU - Jiamsakul, Awachana

AU - Sungkanuparph, Somnuek

AU - Kumarasamy, Nagalingeswaran

AU - Lee, Man Po

AU - Sirisanthana, Thira

AU - Kantipong, Pacharee

AU - Lee, Christopher

AU - Kamarulzaman, Adeeba

AU - Mustafa, Mahiran

AU - Ditangco, Rossana

AU - Merati, Tuti

AU - Ratanasuwan, Winai

AU - Singtoroj, Thida

AU - Kantor, Rami

PY - 2014/5/1

Y1 - 2014/5/1

N2 - BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

AB - BACKGROUND: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens. METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models. RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR. CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

KW - ART outcome

KW - HIV-1

KW - South East Asia

KW - transmitted drug resistance

UR - https://www.scopus.com/pages/publications/84898539282

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DO - 10.1097/QAI.0000000000000108

M3 - Article

C2 - 24413039

AN - SCOPUS:84898539282

SN - 1525-4135

VL - 66

SP - 74

EP - 79

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

IS - 1

ER -

Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in south east asia

Abstract

UN SDGs

Keywords

Access to Document

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