TY - JOUR
T1 - Translational Potential of RNA Derived From Extracellular Vesicles in Multiple Myeloma
AU - Reale, Antonia
AU - Khong, Tiffany
AU - Mithraprabhu, Sridurga
AU - Spencer, Andrew
N1 - Funding Information:
This work was supported by Monash University, Melbourne, Australia – Australian Government Training Program (RTP) scholarship and Monash Departmental Scholarship (AR).
Publisher Copyright:
© Copyright © 2021 Reale, Khong, Mithraprabhu and Spencer.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/8/27
Y1 - 2021/8/27
N2 - The cross-talk between tumour cells and stromal cells is a hallmark of multiple myeloma (MM), a blood cancer that still remains incurable despite increased knowledge of its biology and advances in its treatment. Extracellular vesicles (EVs) derived from both tumour and stromal cells have been shown to play an important role in mediating this cross-talk ultimately favouring MM progression and drug resistance. Furthermore, EVs and their content including RNA (EV-RNA) have been successfully isolated from blood and are being explored as liquid biomarkers in MM with the potential to improve diagnosis and monitoring modalities with a minimally-invasive and repeatable analysis, i.e. liquid biopsy. In this review, we describe both the role of EV-RNA in defining the biological features of MM and their potential translational relevance as liquid biomarkers, therapeutic targets and delivery systems. We also discuss the limitations and technical challenges related to the isolation and characterization of EVs and provide a perspective on the future of MM-derived EV-RNA in translational research.
AB - The cross-talk between tumour cells and stromal cells is a hallmark of multiple myeloma (MM), a blood cancer that still remains incurable despite increased knowledge of its biology and advances in its treatment. Extracellular vesicles (EVs) derived from both tumour and stromal cells have been shown to play an important role in mediating this cross-talk ultimately favouring MM progression and drug resistance. Furthermore, EVs and their content including RNA (EV-RNA) have been successfully isolated from blood and are being explored as liquid biomarkers in MM with the potential to improve diagnosis and monitoring modalities with a minimally-invasive and repeatable analysis, i.e. liquid biopsy. In this review, we describe both the role of EV-RNA in defining the biological features of MM and their potential translational relevance as liquid biomarkers, therapeutic targets and delivery systems. We also discuss the limitations and technical challenges related to the isolation and characterization of EVs and provide a perspective on the future of MM-derived EV-RNA in translational research.
KW - biomarker
KW - extracellular vesicles
KW - liquid biopsy
KW - myeloma
KW - RNA
KW - translational medicine
KW - tumour microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85114710696&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.718502
DO - 10.3389/fonc.2021.718502
M3 - Review Article
C2 - 34513695
AN - SCOPUS:85114710696
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 718502
ER -