Translatable Models of Brain and Cognitive Reserve

Ariel Zeleznikow-Johnston; Emma L Burrows; Thibault Renoir; Anthony J Hannan

doi:10.1007/978-3-319-52067-4_4

Translatable Models of Brain and Cognitive Reserve

Ariel Zeleznikow-Johnston, Emma L Burrows, Thibault Renoir, Anthony J Hannan

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

The observation of variation in levels of neuropathology required for individuals to develop cognitive deficits led to the theory of ‘brain and cognitive reserve’ (BCR). This theory posits that there are intrinsic and environmental factors that modify the probability that an individual will develop a neurological disorder in response to a given insult. The development of animal models has allowed this theory to be tested, with rodent experiments demonstrating how environmental factors such as environmental enrichment and exercise levels can ameliorate models of ageing, neurodegeneration and brain injury. Physiological studies in these animal models have identified putative neurobiological mediators of improved BCR from the molecular to anatomical level. Improvements in the development of these models will enable improved testing of the BCR theory and further aid in the quest for developing enviromimetic drugs.

Original language	English
Title of host publication	Neurobiological and Psychological Aspects of Brain Recovery
Editors	Laura Petrosini
Place of Publication	Switzerland
Publisher	Springer
Chapter	4
Pages	79-104
Number of pages	26
ISBN (Electronic)	9783319520674
ISBN (Print)	9783319520650
DOIs	https://doi.org/10.1007/978-3-319-52067-4_4
Publication status	Published - 2017
Externally published	Yes

Access to Document

10.1007/978-3-319-52067-4_4

1 Chapter (Book)

Translatable Models of Brain and Cognitive Reserve
Zeleznikow-Johnston, A. M., Burrows, E. L., Renoir, T. & Hannan, A. J., 2023, Neurobiological and Psychological Aspects of Brain Recovery. Petrosini, L. (ed.). 2nd ed. Switzerland: Springer, p. 93-119 27 p. (Contemporary Clinical Neuroscience; vol. Part F276).
Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Cite this

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title = "Translatable Models of Brain and Cognitive Reserve",

abstract = "The observation of variation in levels of neuropathology required for individuals to develop cognitive deficits led to the theory of {\textquoteleft}brain and cognitive reserve{\textquoteright} (BCR). This theory posits that there are intrinsic and environmental factors that modify the probability that an individual will develop a neurological disorder in response to a given insult. The development of animal models has allowed this theory to be tested, with rodent experiments demonstrating how environmental factors such as environmental enrichment and exercise levels can ameliorate models of ageing, neurodegeneration and brain injury. Physiological studies in these animal models have identified putative neurobiological mediators of improved BCR from the molecular to anatomical level. Improvements in the development of these models will enable improved testing of the BCR theory and further aid in the quest for developing enviromimetic drugs.",

author = "Ariel Zeleznikow-Johnston and Burrows, {Emma L} and Thibault Renoir and Hannan, {Anthony J}",

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AU - Renoir, Thibault

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AB - The observation of variation in levels of neuropathology required for individuals to develop cognitive deficits led to the theory of ‘brain and cognitive reserve’ (BCR). This theory posits that there are intrinsic and environmental factors that modify the probability that an individual will develop a neurological disorder in response to a given insult. The development of animal models has allowed this theory to be tested, with rodent experiments demonstrating how environmental factors such as environmental enrichment and exercise levels can ameliorate models of ageing, neurodegeneration and brain injury. Physiological studies in these animal models have identified putative neurobiological mediators of improved BCR from the molecular to anatomical level. Improvements in the development of these models will enable improved testing of the BCR theory and further aid in the quest for developing enviromimetic drugs.

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