Transient visual pathway critical for normal development of primate grasping behavior

Inaki-Carril Mundinano, Dylan M. Fox, William C. Kwan, Diego Vidaurre, Leon Teo, Jihane Homman-Ludiye, Melvyn A. Goodale, David A. Leopold, James A. Bourne

Research output: Contribution to journalArticleResearchpeer-review

Abstract

An evolutionary hallmark of anthropoid primates, including humans, is the use of vision to guide precise manual movements. These behaviors are reliant on a specialized visual input to the posterior parietal cortex. Here, we show that normal primate reaching-and-grasping behavior depends critically on a visual pathway through the thalamic pulvinar, which is thought to relay information to the middle temporal (MT) area during early life and then swiftly withdraws. Small MRI-guided lesions to a subdivision of the inferior pulvinar subnucleus (PIm) in the infant marmoset monkey led to permanent deficits in reaching-and-grasping behavior in the adult. This functional loss coincided with the abnormal anatomical development of multiple cortical areas responsible for the guidance of actions. Our study reveals that the transient retino-pulvinar-MT pathway underpins the development of visually guided manual behaviors in primates that are crucial for interacting with complex features in the environment.

Original languageEnglish
Pages (from-to)1364-1369
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number6
DOIs
Publication statusPublished - 6 Feb 2018

Keywords

  • Marmoset
  • Prehension
  • Pulvinar
  • Thalamus
  • Visual cortex

Cite this

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title = "Transient visual pathway critical for normal development of primate grasping behavior",
abstract = "An evolutionary hallmark of anthropoid primates, including humans, is the use of vision to guide precise manual movements. These behaviors are reliant on a specialized visual input to the posterior parietal cortex. Here, we show that normal primate reaching-and-grasping behavior depends critically on a visual pathway through the thalamic pulvinar, which is thought to relay information to the middle temporal (MT) area during early life and then swiftly withdraws. Small MRI-guided lesions to a subdivision of the inferior pulvinar subnucleus (PIm) in the infant marmoset monkey led to permanent deficits in reaching-and-grasping behavior in the adult. This functional loss coincided with the abnormal anatomical development of multiple cortical areas responsible for the guidance of actions. Our study reveals that the transient retino-pulvinar-MT pathway underpins the development of visually guided manual behaviors in primates that are crucial for interacting with complex features in the environment.",
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Transient visual pathway critical for normal development of primate grasping behavior. / Mundinano, Inaki-Carril; Fox, Dylan M.; Kwan, William C.; Vidaurre, Diego; Teo, Leon; Homman-Ludiye, Jihane; Goodale, Melvyn A.; Leopold, David A.; Bourne, James A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 6, 06.02.2018, p. 1364-1369.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Mundinano, Inaki-Carril

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AU - Vidaurre, Diego

AU - Teo, Leon

AU - Homman-Ludiye, Jihane

AU - Goodale, Melvyn A.

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AU - Bourne, James A.

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