Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The novel environment of a metabolic cage can be stressful for rodents, but few studies have attempted to quantify this stress-response. Therefore, we determined the effects on mean arterial pressure (MAP) and heart rate (HR), of placing mice of both sexes in metabolism cages for 2 days. After surgical implantation of a carotid artery catheter mice recovered individually in standard cages for 5 days. Mice then spent 2 days in metabolism cages. MAP and HR were monitored in the standard cage on Day 5 and in metabolism cages on days 6-7. MAP increased by 18?3 and 22?4 whilst HR increased by 27?4 and 27?6 , in males and females respectively, during the first hour after cage switch. MAP decreased to baseline in the fourth and eighth hour following metabolism cage switch in males and females, respectively. However, HR remained significantly elevated in both sexes during the entire 2 day period in metabolism cages. Females had lower MAP than males both pre- and post-metabolism cage switch, but there were no sex-differences in HR. These results demonstrate sustained changes in cardiovascular function when mice are housed in metabolism cages, which could potentially affect renal function.
Original languageEnglish
Pages (from-to)69 - 75
Number of pages6
JournalPhysiological Research
Volume58
Publication statusPublished - 2009

Cite this

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title = "Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages",
abstract = "The novel environment of a metabolic cage can be stressful for rodents, but few studies have attempted to quantify this stress-response. Therefore, we determined the effects on mean arterial pressure (MAP) and heart rate (HR), of placing mice of both sexes in metabolism cages for 2 days. After surgical implantation of a carotid artery catheter mice recovered individually in standard cages for 5 days. Mice then spent 2 days in metabolism cages. MAP and HR were monitored in the standard cage on Day 5 and in metabolism cages on days 6-7. MAP increased by 18?3 and 22?4 whilst HR increased by 27?4 and 27?6 , in males and females respectively, during the first hour after cage switch. MAP decreased to baseline in the fourth and eighth hour following metabolism cage switch in males and females, respectively. However, HR remained significantly elevated in both sexes during the entire 2 day period in metabolism cages. Females had lower MAP than males both pre- and post-metabolism cage switch, but there were no sex-differences in HR. These results demonstrate sustained changes in cardiovascular function when mice are housed in metabolism cages, which could potentially affect renal function.",
author = "Hoppe, {Chantal Christiana} and Moritz, {Karen Margaret} and Fitzgerald, {Sharyn M} and Bertram, {John Frederick} and Evans, {Roger George}",
year = "2009",
language = "English",
volume = "58",
pages = "69 -- 75",
journal = "Physiological Research",
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Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages. / Hoppe, Chantal Christiana; Moritz, Karen Margaret; Fitzgerald, Sharyn M; Bertram, John Frederick; Evans, Roger George.

In: Physiological Research, Vol. 58, 2009, p. 69 - 75.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages

AU - Hoppe, Chantal Christiana

AU - Moritz, Karen Margaret

AU - Fitzgerald, Sharyn M

AU - Bertram, John Frederick

AU - Evans, Roger George

PY - 2009

Y1 - 2009

N2 - The novel environment of a metabolic cage can be stressful for rodents, but few studies have attempted to quantify this stress-response. Therefore, we determined the effects on mean arterial pressure (MAP) and heart rate (HR), of placing mice of both sexes in metabolism cages for 2 days. After surgical implantation of a carotid artery catheter mice recovered individually in standard cages for 5 days. Mice then spent 2 days in metabolism cages. MAP and HR were monitored in the standard cage on Day 5 and in metabolism cages on days 6-7. MAP increased by 18?3 and 22?4 whilst HR increased by 27?4 and 27?6 , in males and females respectively, during the first hour after cage switch. MAP decreased to baseline in the fourth and eighth hour following metabolism cage switch in males and females, respectively. However, HR remained significantly elevated in both sexes during the entire 2 day period in metabolism cages. Females had lower MAP than males both pre- and post-metabolism cage switch, but there were no sex-differences in HR. These results demonstrate sustained changes in cardiovascular function when mice are housed in metabolism cages, which could potentially affect renal function.

AB - The novel environment of a metabolic cage can be stressful for rodents, but few studies have attempted to quantify this stress-response. Therefore, we determined the effects on mean arterial pressure (MAP) and heart rate (HR), of placing mice of both sexes in metabolism cages for 2 days. After surgical implantation of a carotid artery catheter mice recovered individually in standard cages for 5 days. Mice then spent 2 days in metabolism cages. MAP and HR were monitored in the standard cage on Day 5 and in metabolism cages on days 6-7. MAP increased by 18?3 and 22?4 whilst HR increased by 27?4 and 27?6 , in males and females respectively, during the first hour after cage switch. MAP decreased to baseline in the fourth and eighth hour following metabolism cage switch in males and females, respectively. However, HR remained significantly elevated in both sexes during the entire 2 day period in metabolism cages. Females had lower MAP than males both pre- and post-metabolism cage switch, but there were no sex-differences in HR. These results demonstrate sustained changes in cardiovascular function when mice are housed in metabolism cages, which could potentially affect renal function.

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