Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes

Agnes A. Michalczyk; Edward D. Janus; Alisha Judge; Peter R. Ebeling; James D. Best; Michael J. Ackland; Dino Asproloupos; James A. Dunbar; M. Leigh Ackland

doi:10.2217/epi-2017-0129

Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes

Agnes A. Michalczyk
, Edward D. Janus
, Alisha Judge
, Peter R. Ebeling
, James D. Best
, Michael J. Ackland
, Dino Asproloupos
, James A. Dunbar
, M. Leigh Ackland

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Aim: To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. Methods: Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. Results: Dimethylation levels of all five histones were different between women in pregnancy and early postpartum compared with never-pregnant women and were different between women with and without type 2 diabetes. Conclusion: Histone methylation changes are transient in pregnancy and early postpartum and may represent normal physiological responses to hormones. Different epigenomic profiles in women with type 2 diabetes mellitus may correlate with hormonal responses, leading to high risk pregnancy outcomes.

Original language	English
Pages (from-to)	419-431
Number of pages	13
Journal	Epigenomics
Volume	10
Issue number	4
DOIs	https://doi.org/10.2217/epi-2017-0129
Publication status	Published - 1 Jan 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

epigenetics
histone methylation
pregnancy
type 2 diabetes mellitus

Access to Document

10.2217/epi-2017-0129

286429289-oaFinal published version, 1.52 MB

Cite this

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title = "Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes",

abstract = "Aim: To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. Methods: Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. Results: Dimethylation levels of all five histones were different between women in pregnancy and early postpartum compared with never-pregnant women and were different between women with and without type 2 diabetes. Conclusion: Histone methylation changes are transient in pregnancy and early postpartum and may represent normal physiological responses to hormones. Different epigenomic profiles in women with type 2 diabetes mellitus may correlate with hormonal responses, leading to high risk pregnancy outcomes.",

keywords = "epigenetics, histone methylation, pregnancy, type 2 diabetes mellitus",

author = "Michalczyk, \{Agnes A.\} and Janus, \{Edward D.\} and Alisha Judge and Ebeling, \{Peter R.\} and Best, \{James D.\} and Ackland, \{Michael J.\} and Dino Asproloupos and Dunbar, \{James A.\} and Ackland, \{M. Leigh\}",

year = "2018",

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day = "1",

doi = "10.2217/epi-2017-0129",

language = "English",

volume = "10",

pages = "419--431",

journal = "Epigenomics",

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TY - JOUR

T1 - Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes

AU - Michalczyk, Agnes A.

AU - Janus, Edward D.

AU - Judge, Alisha

AU - Ebeling, Peter R.

AU - Best, James D.

AU - Ackland, Michael J.

AU - Asproloupos, Dino

AU - Dunbar, James A.

AU - Ackland, M. Leigh

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. Methods: Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. Results: Dimethylation levels of all five histones were different between women in pregnancy and early postpartum compared with never-pregnant women and were different between women with and without type 2 diabetes. Conclusion: Histone methylation changes are transient in pregnancy and early postpartum and may represent normal physiological responses to hormones. Different epigenomic profiles in women with type 2 diabetes mellitus may correlate with hormonal responses, leading to high risk pregnancy outcomes.

AB - Aim: To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. Methods: Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. Results: Dimethylation levels of all five histones were different between women in pregnancy and early postpartum compared with never-pregnant women and were different between women with and without type 2 diabetes. Conclusion: Histone methylation changes are transient in pregnancy and early postpartum and may represent normal physiological responses to hormones. Different epigenomic profiles in women with type 2 diabetes mellitus may correlate with hormonal responses, leading to high risk pregnancy outcomes.

KW - epigenetics

KW - histone methylation

KW - pregnancy

KW - type 2 diabetes mellitus

UR - https://www.scopus.com/pages/publications/85045525207

U2 - 10.2217/epi-2017-0129

DO - 10.2217/epi-2017-0129

M3 - Article

C2 - 29561170

AN - SCOPUS:85045525207

SN - 1750-1911

VL - 10

SP - 419

EP - 431

JO - Epigenomics

JF - Epigenomics

IS - 4

ER -

Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes

Abstract

UN SDGs

Keywords

Access to Document

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