TY - JOUR
T1 - Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats
AU - Gallo, Linda A
AU - Tran, Melanie
AU - Cullen-McEwen, Luise A
AU - Denton, Katherine M
AU - Jefferies, Andrew J
AU - Moritz, Karen M
AU - Wlodek, Mary E
PY - 2014
Y1 - 2014
N2 - A developmental insult that restricts growth in the first generation has the potential to program disease in subsequent generations. The aim of this study was to ascertain transgenerational growth and cardio-renal effects, via the maternal line, in a rat model of utero-placental insufficiency. Bilateral uterine vessel ligation or sham surgery (offspring termed first generation; F1 Restricted and Control, respectively) was performed in WKY rats. F1 Restricted and Control females were mated with normal males to produce second generation (F2) offspring (Restricted and Control) studied from fetal (embryonic Day 20) to adult (12 months) life. F2 Restricted male and female fetuses had reduced (P
AB - A developmental insult that restricts growth in the first generation has the potential to program disease in subsequent generations. The aim of this study was to ascertain transgenerational growth and cardio-renal effects, via the maternal line, in a rat model of utero-placental insufficiency. Bilateral uterine vessel ligation or sham surgery (offspring termed first generation; F1 Restricted and Control, respectively) was performed in WKY rats. F1 Restricted and Control females were mated with normal males to produce second generation (F2) offspring (Restricted and Control) studied from fetal (embryonic Day 20) to adult (12 months) life. F2 Restricted male and female fetuses had reduced (P
UR - http://www.publish.csiro.au.ezproxy.lib.monash.edu.au/?act=view_file&file_id=RD13133.pdf
U2 - 10.1071/RD13133
DO - 10.1071/RD13133
M3 - Article
VL - 26
SP - 1032
EP - 1043
JO - Reproduction, Fertility and Development
JF - Reproduction, Fertility and Development
SN - 1031-3613
IS - 7
ER -