Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats

Linda A Gallo, Melanie Tran, Luise A Cullen-McEwen, Katherine M Denton, Andrew J Jefferies, Karen M Moritz, Mary E Wlodek

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36 Citations (Scopus)


A developmental insult that restricts growth in the first generation has the potential to program disease in subsequent generations. The aim of this study was to ascertain transgenerational growth and cardio-renal effects, via the maternal line, in a rat model of utero-placental insufficiency. Bilateral uterine vessel ligation or sham surgery (offspring termed first generation; F1 Restricted and Control, respectively) was performed in WKY rats. F1 Restricted and Control females were mated with normal males to produce second generation (F2) offspring (Restricted and Control) studied from fetal (embryonic Day 20) to adult (12 months) life. F2 Restricted male and female fetuses had reduced (P
Original languageEnglish
Pages (from-to)1032 - 1043
Number of pages12
JournalReproduction, Fertility and Development
Issue number7
Publication statusPublished - 2014

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