Transforming growth factor-beta, MAPK and Wnt signaling interactions in colorectal cancer

Harish R Cheruku, Abidali Mohamedali, David I Cantor, Sock-Hwee Tan, Edouard Nice, Mark S Baker

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)


In non-cancerous cells, transforming growth factor-b (TGFb) regulates cellular responses primarily through Smad signaling. However, during cancer progression (including colorectal) TGFb promotes tumoral growth via Smad-independent mechanisms and is involved in crosstalk with various pathways like the mitogen-activated protein kinases (MAPK) and Wnt. Crosstalk between these pathways following activation by TGFb and subsequent downstream signaling activity can be referred to as a crosstalk signaling signature. This review highlights the progress in understanding TGFb signaling crosstalk involving various MAPK pathway members (e.g., extracellular signal-regulated kinase (Erk) 1/2, Ras, c-Jun N-terminal kinases (JNK) and p38) and the Wnt signaling pathway.
Original languageEnglish
Pages (from-to)104 - 115
Number of pages12
JournalEuPA Open Proteomics
Publication statusPublished - 2015

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