Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses

Belinda Thomas, Mandy Lee Lindsay, Hayat Dagher, Nick Freezer, Dongsheng Li, Reena Ghildyal, Philip Bardin

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

Transforming growth factor (TGF)beta is increased in asthma and may suppress immune responses. It is unknown whether TGF-beta activity may impact on rhinovirus infections and play a role in virus-associated asthma exacerbations. TGF-beta mediates enhanced rhinovirus replication probably probably via its suppressive actions on host type 1 interferon responses.
Original languageEnglish
Pages (from-to)339 - 347
Number of pages9
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume41
Issue number3
DOIs
Publication statusPublished - 2009

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