Transforming growth factor (TGF)beta is increased in asthma and may suppress immune responses. It is unknown whether TGF-beta activity may impact on rhinovirus infections and play a role in virus-associated asthma exacerbations. TGF-beta mediates enhanced rhinovirus replication probably probably via its suppressive actions on host type 1 interferon responses.
|Pages (from-to)||339 - 347|
|Number of pages||9|
|Journal||American Journal of Respiratory Cell and Molecular Biology|
|Publication status||Published - 2009|
Thomas, B., Lindsay, M. L., Dagher, H., Freezer, N., Li, D., Ghildyal, R., & Bardin, P. (2009). Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses. American Journal of Respiratory Cell and Molecular Biology, 41(3), 339 - 347. https://doi.org/10.1165/2008-0316OC