Abstract
The process of nephrogenesis and the number of nephrons formed during kidney development are both highly dependent upon ureteric branching morphogenesis. Abnormalities in branching and growth of the ureter have been implicated in a range of urogenital/renal pathologies including cystic renal disease and some forms of renal agenesis. The issue of how the branching of the ureter is regulated is therefore an important one. There is a growing list of candidate molecules (growth factors, oncogenes, transcription factors and extracellular matrix components) which have been directly or indirectly implicated in the regulation of ureteric branching. Among these, members of the transforming growth factor-β (TGF-β) superfamily are well represented. This review summarizes our knowledge of the roles of TGF-β superfamily members in ureteric branching morphogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 274-284 |
| Number of pages | 11 |
| Journal | Nephrology |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Jan 2001 |
Keywords
- Branching morphogenesis
- Metanephros
- Superfamily
- TGF-β
Cite this
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Transforming growth factor-β superfamily members : Roles in branching morphogenesis in the kidney. / Martinez, Gemma; Cullen-McEwen, Luise A.; Bertram, John F.
In: Nephrology, Vol. 6, No. 6, 01.01.2001, p. 274-284.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Transforming growth factor-β superfamily members
T2 - Roles in branching morphogenesis in the kidney
AU - Martinez, Gemma
AU - Cullen-McEwen, Luise A.
AU - Bertram, John F.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The process of nephrogenesis and the number of nephrons formed during kidney development are both highly dependent upon ureteric branching morphogenesis. Abnormalities in branching and growth of the ureter have been implicated in a range of urogenital/renal pathologies including cystic renal disease and some forms of renal agenesis. The issue of how the branching of the ureter is regulated is therefore an important one. There is a growing list of candidate molecules (growth factors, oncogenes, transcription factors and extracellular matrix components) which have been directly or indirectly implicated in the regulation of ureteric branching. Among these, members of the transforming growth factor-β (TGF-β) superfamily are well represented. This review summarizes our knowledge of the roles of TGF-β superfamily members in ureteric branching morphogenesis.
AB - The process of nephrogenesis and the number of nephrons formed during kidney development are both highly dependent upon ureteric branching morphogenesis. Abnormalities in branching and growth of the ureter have been implicated in a range of urogenital/renal pathologies including cystic renal disease and some forms of renal agenesis. The issue of how the branching of the ureter is regulated is therefore an important one. There is a growing list of candidate molecules (growth factors, oncogenes, transcription factors and extracellular matrix components) which have been directly or indirectly implicated in the regulation of ureteric branching. Among these, members of the transforming growth factor-β (TGF-β) superfamily are well represented. This review summarizes our knowledge of the roles of TGF-β superfamily members in ureteric branching morphogenesis.
KW - Branching morphogenesis
KW - Metanephros
KW - Superfamily
KW - TGF-β
UR - http://www.scopus.com/inward/record.url?scp=0346997775&partnerID=8YFLogxK
U2 - 10.1046/j.1440-1797.2001.00070.x
DO - 10.1046/j.1440-1797.2001.00070.x
M3 - Article
VL - 6
SP - 274
EP - 284
JO - Nephrology
JF - Nephrology
SN - 1320-5358
IS - 6
ER -