Transfer of murine experimental autoimmune encephalomyelitis and cell-mediated immunity to myelin protein is effected by Lyt-1 cells

Claude C A Bernard, Ian R. Mackay

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cellular transfer of experimental autoimmune encephalomyelitis (EAE) was effected in mice with lymph node cells (LNC) from appropriately immunized donors. Pretreatment of LNC with anti-Lyt-1 and antibodies indicated that the transfer of both EAE and a cell-mediated immune response in vitro to MBP was dependent on a subpopulation of T lymphocytes expressing the phenotype associated with the helper and cell-mediated delayed hypersensitivity functions, Lyt-1+, 2-.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalJournal of Neuroimmunology
Volume4
Issue number1
DOIs
Publication statusPublished - 1983

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