Transfer of donor anti-HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?

Megan Kummrow, Steven Hiho, Fiona Hudson, Linda Cantwell, William R. Mulley, Lloyd D'Orsogna, Adam Testro, Julie Pavlovic, Peter MacDonald, Lucy C. Sullivan, Gregory I. Snell, Glen P. Westall

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Antibody-mediated rejection, whereby transplant recipient B cells and/or plasma cells produce alloreactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early posttransplant coexistence of a shared anti-HLA antibody profile in 5 solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the passenger lymphocyte syndrome. These findings have important implications for the consideration of all posttransplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients.

Original languageEnglish
Pages (from-to)1577-1581
Number of pages5
JournalAmerican Journal of Transplantation
Volume19
Issue number5
DOIs
Publication statusPublished - May 2019
Externally publishedYes

Keywords

  • clinical research/practice
  • crossmatch
  • histocompatibility
  • lung (allograft) function/dysfunction
  • lung transplantation/pulmonology
  • major histocompatibility complex (MHC)
  • organ transplantation in general
  • rejection: antibody-mediated (ABMR)

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