Transfer entropy analysis of maternal and fetal heart rate coupling

Faezeh Marzbanrad, Yoshitaka Kimura, Miyuki Endo, Marimuthu Palaniswami, Ahsan H Khandoker

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

4 Citations (Scopus)

Abstract

Although evidence of the short term relationship between maternal and fetal heart rates has been found in previous model-based studies, knowledge about the mechanism and patterns of the coupling during gestation is still limited. In this study, a model-free method based on Transfer Entropy (TE) was applied to quantify the maternal-fetal heart rate couplings in both directions. Furthermore, analysis of the lag at which TE was maximum and its changes throughout gestation, provided more information about the mechanism of coupling and its latency. Experimental results based on fetal electrocardiograms (fECGs) and maternal ECG showed the evidence of coupling for 62 out of 65 healthy mothers and fetuses in each direction, by statistically validating against the surrogate pairs. The fetuses were divided into three gestational age groups: early (16-25 weeks), mid (26-31 weeks) and late (32-41 weeks) gestation. The maximum TE from maternal to fetal heart rate significantly increased from early to mid gestation, while the coupling delay on both directions decreased significantly from mid to late gestation. These changes occur concomitant with the maturation of the fetal sensory and autonomic nervous systems with advancing gestational age. In conclusion, the application of TE with delays revealed detailed information about the changes in fetal-maternal heart rate coupling strength and latency throughout gestation, which could provide novel clinical markers of fetal development and well-being.
Original languageEnglish
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015)
EditorsJim Patton
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages7865-7868
Number of pages4
ISBN (Electronic)9781424492718
ISBN (Print)9781424492701
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2015: Biomedical Engineering: A bridge to improve the quality of health care and the quality of life - MiCo - Milano Congressi Center, Milan, Italy
Duration: 25 Aug 201529 Aug 2015
Conference number: 37th
https://embc.embs.org/2015/

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2015
Abbreviated titleEMBC 2015
CountryItaly
CityMilan
Period25/08/1529/08/15
Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). Our Annual Conference (known as EMBC) is a premier international conference in biomedical engineering, and has been strategically held in different locations around the world, including Chicago, Osaka, San Diego, Boston, Buenos Aires, Minneapolis, Vancouver, Lyon, New York, and Shanghai over the last 10 years.
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