Heterogeneous base catalysts were studied to develop an effective biodiesel manufacturing process with high activity and durability. Investigations were conducted on solid base CaO-MgO mixed metal oxides with different Ca/Mg atomic ratios. These catalysts were characterized by X-ray diffraction (XRD), nitrogen sorption with Brunauer-Emmer-Teller method (BET surface area), scanning electron microscopy (SEM) with energy dispersive X-ray (EDS) spectroscopy and temperature-programmed desorption of CO(2) (TPD-CO(2)). The catalytic activity was evaluated by transesterification of non-edible oil (Jatropha curcas oil) to its corresponding fatty acid methyl ester. Under optimum condition: 3 h reaction time, 25:1 methanol/oil molar ratio, 3 wt. catalyst loading and 120 degrees C reaction temperature, a series of calcium-based mixed oxide catalysts with different Ca/Mg atomic ratio produced a FAME yield in the range of 75-90 .