Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy

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Abstract

Objective: The aim of this study was to examine the effects of testosterone on verbal learning and memory in postmenopausal women. Design: Randomized, placebo-controlled trial in which participants were randomized (1:1) to transdermal testosterone gel 300 mcg/day, or identical placebo, for 26 weeks. Patients: Ninety-two postmenopausal women aged 55-65 years, on no systemic sex hormone therapy. Measurements: The primary outcome was the score for the International Shopping List Task (ISLT) of CogState. Secondary outcomes included other CogState domains, the Psychological General Well-Being Index (PGWB) and safety variables. Results: Eighty-nine women, median age 60 years, were included in the primary analysis. Testosterone treatment resulted in statistically significantly better performance for the ISLT (improved verbal learning and memory) compared with placebo, adjusted for age and baseline score (mean difference 1?57; 95 CI 0?13, 3?01) P = 0?03). There were no significant differences for other CogState domains or the PGWB scores. At 26 weeks, the median total testosterone was 1?7 nm (interquartile range (IQR) 1?1, 2?4) in the testosterone group and 0?4 nm (IQR 0?3, 0?5) in the placebo group. Conclusions: The small but statistically significant effect of testosterone treatment on verbal learning and memory in postmenopausal women provides the basis for further clinical trials.
Original languageEnglish
Pages (from-to)621 - 628
Number of pages8
JournalClinical Endocrinology
Volume81
Issue number4
DOIs
Publication statusPublished - 2014

Cite this

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title = "Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy",
abstract = "Objective: The aim of this study was to examine the effects of testosterone on verbal learning and memory in postmenopausal women. Design: Randomized, placebo-controlled trial in which participants were randomized (1:1) to transdermal testosterone gel 300 mcg/day, or identical placebo, for 26 weeks. Patients: Ninety-two postmenopausal women aged 55-65 years, on no systemic sex hormone therapy. Measurements: The primary outcome was the score for the International Shopping List Task (ISLT) of CogState. Secondary outcomes included other CogState domains, the Psychological General Well-Being Index (PGWB) and safety variables. Results: Eighty-nine women, median age 60 years, were included in the primary analysis. Testosterone treatment resulted in statistically significantly better performance for the ISLT (improved verbal learning and memory) compared with placebo, adjusted for age and baseline score (mean difference 1?57; 95 CI 0?13, 3?01) P = 0?03). There were no significant differences for other CogState domains or the PGWB scores. At 26 weeks, the median total testosterone was 1?7 nm (interquartile range (IQR) 1?1, 2?4) in the testosterone group and 0?4 nm (IQR 0?3, 0?5) in the placebo group. Conclusions: The small but statistically significant effect of testosterone treatment on verbal learning and memory in postmenopausal women provides the basis for further clinical trials.",
author = "Davis, {Susan Ruth} and Jane, {Fiona Margaret} and Robinson, {Penelope Jane} and Davison, {Sonia Louise} and Roisin Worsley and Maruff, {Paul M} and Bell, {Robin Jean}",
year = "2014",
doi = "10.1111/cen.12459",
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}

Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy. / Davis, Susan Ruth; Jane, Fiona Margaret; Robinson, Penelope Jane; Davison, Sonia Louise; Worsley, Roisin; Maruff, Paul M; Bell, Robin Jean.

In: Clinical Endocrinology, Vol. 81, No. 4, 2014, p. 621 - 628.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy

AU - Davis, Susan Ruth

AU - Jane, Fiona Margaret

AU - Robinson, Penelope Jane

AU - Davison, Sonia Louise

AU - Worsley, Roisin

AU - Maruff, Paul M

AU - Bell, Robin Jean

PY - 2014

Y1 - 2014

N2 - Objective: The aim of this study was to examine the effects of testosterone on verbal learning and memory in postmenopausal women. Design: Randomized, placebo-controlled trial in which participants were randomized (1:1) to transdermal testosterone gel 300 mcg/day, or identical placebo, for 26 weeks. Patients: Ninety-two postmenopausal women aged 55-65 years, on no systemic sex hormone therapy. Measurements: The primary outcome was the score for the International Shopping List Task (ISLT) of CogState. Secondary outcomes included other CogState domains, the Psychological General Well-Being Index (PGWB) and safety variables. Results: Eighty-nine women, median age 60 years, were included in the primary analysis. Testosterone treatment resulted in statistically significantly better performance for the ISLT (improved verbal learning and memory) compared with placebo, adjusted for age and baseline score (mean difference 1?57; 95 CI 0?13, 3?01) P = 0?03). There were no significant differences for other CogState domains or the PGWB scores. At 26 weeks, the median total testosterone was 1?7 nm (interquartile range (IQR) 1?1, 2?4) in the testosterone group and 0?4 nm (IQR 0?3, 0?5) in the placebo group. Conclusions: The small but statistically significant effect of testosterone treatment on verbal learning and memory in postmenopausal women provides the basis for further clinical trials.

AB - Objective: The aim of this study was to examine the effects of testosterone on verbal learning and memory in postmenopausal women. Design: Randomized, placebo-controlled trial in which participants were randomized (1:1) to transdermal testosterone gel 300 mcg/day, or identical placebo, for 26 weeks. Patients: Ninety-two postmenopausal women aged 55-65 years, on no systemic sex hormone therapy. Measurements: The primary outcome was the score for the International Shopping List Task (ISLT) of CogState. Secondary outcomes included other CogState domains, the Psychological General Well-Being Index (PGWB) and safety variables. Results: Eighty-nine women, median age 60 years, were included in the primary analysis. Testosterone treatment resulted in statistically significantly better performance for the ISLT (improved verbal learning and memory) compared with placebo, adjusted for age and baseline score (mean difference 1?57; 95 CI 0?13, 3?01) P = 0?03). There were no significant differences for other CogState domains or the PGWB scores. At 26 weeks, the median total testosterone was 1?7 nm (interquartile range (IQR) 1?1, 2?4) in the testosterone group and 0?4 nm (IQR 0?3, 0?5) in the placebo group. Conclusions: The small but statistically significant effect of testosterone treatment on verbal learning and memory in postmenopausal women provides the basis for further clinical trials.

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