Transcriptional regulation by the Set7 lysine methyltransferase

Samuel T Keating, Assam El-Osta

Research output: Contribution to journalReview ArticleResearchpeer-review

49 Citations (Scopus)

Abstract

Posttranslational histone modifications define chromatin structure and function. In recent years, a number of studies have characterized many of the enzymatic activities and diverse regulatory components required for monomethylation of histone H3 lysine 4 (H3K4me1) and the expression of specific genes. The challenge now is to understand how this specific chemical modification is written and the Set7 methyltransferase has emerged as a key regulatory enzyme mediating methylation of lysine residues of histone and non-histone proteins. In this review, we comprehensively explore the regulatory proteins modified by Set7 and highlight mechanisms of specific co-recruitment of the enzyme to activating promoters. With a focus on signaling and transcriptional control in disease we discuss recent experimental data emphasizing specific components of diverse regulatory complexes that mediate chromatin modification and reinterpretation of Set7-mediated gene expression.

Original languageEnglish
Pages (from-to)361-372
Number of pages12
JournalEpigenetics
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Apr 2013

Keywords

  • chromatin
  • epigenetics
  • gene expression
  • histone modification
  • lysine methylation
  • metabolic memory
  • p65
  • Set7
  • Set9

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