Transcriptional profiling technology for studying vaccine responses: an untapped goldmine

Katie L Flanagan, Fatou Noho-Konteh, Peter Ghazal, Paul Dickinson

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

There is much that we do not understand about the immune mechanisms whereby vaccines exert their specific and non-specific effects. Most studies take the reductionist approach of examining vaccine responses at the humoral or cellular level. Whole human transcriptional profiling is becoming more accessible, and provides a picture of the entire immune response to vaccination in a single snapshot . The potential uses of such information are enormous, and the data mining tools are becoming more sophisticated to handle the complex data generated. We now face the exciting prospect of gaining in depth knowledge as to exactly what vaccines do to the immune system as a whole, and identifying molecular signatures and biomarkers that can predict immediate and long term outcomes of vaccination. The challenge now is to carry out the studies and generate the much needed data. ? 2013 Elsevier Inc.
Original languageEnglish
Pages (from-to)269 - 274
Number of pages6
JournalMethods
Volume60
Issue number3
DOIs
Publication statusPublished - 2013

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