TY - JOUR
T1 - Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System
AU - Kallies, Axel
AU - Good-Jacobson, Kim L.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte populations require T-bet for their development or differentiation in response to antigen. Furthermore, other Th cell populations, including T follicular helper and Th17, as well as regulatory T cells can co-opt T-bet expression to promote functional diversification and colocalization. Thus, T-bet broadly regulates transcriptional programs in response to type 1 inflammatory signals and mediates the coordinated differentiation, function, migration and survival of effector and memory lymphocyte subsets in the affected tissue. Therefore, T-bet expression is essential for effective clearance of pathogens and maintenance of immunity.
AB - T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte populations require T-bet for their development or differentiation in response to antigen. Furthermore, other Th cell populations, including T follicular helper and Th17, as well as regulatory T cells can co-opt T-bet expression to promote functional diversification and colocalization. Thus, T-bet broadly regulates transcriptional programs in response to type 1 inflammatory signals and mediates the coordinated differentiation, function, migration and survival of effector and memory lymphocyte subsets in the affected tissue. Therefore, T-bet expression is essential for effective clearance of pathogens and maintenance of immunity.
UR - http://www.scopus.com/inward/record.url?scp=85014490223&partnerID=8YFLogxK
U2 - 10.1016/j.it.2017.02.003
DO - 10.1016/j.it.2017.02.003
M3 - Review Article
AN - SCOPUS:85014490223
SN - 1471-4906
VL - 38
SP - 287
EP - 297
JO - Trends in Immunology
JF - Trends in Immunology
IS - 4
ER -