Transcranial magnetic stimulation and peristimulus frequencygram

Gabrielle Todd, Nigel Craig Rogasch, Kemal Turker

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

The aim of our study was to use peristimulus frequencygram psf) constructed from single motor unit recordings to further characterise the responses evoked by low intensity tms. Twelve healthy subjects (age 32 ? 11 years) received single-pulse tms over the first dorsal interosseus (fdi) motor area during weak isometric index finger abduction. Several hundred stimuli were delivered at a frequency of 0.3.hz and at an intensity of 79-110 of active motor threshold. fdi electromyogram (emg) was recorded with surface and intramuscular fine wire electrodes. For single motor units, data analysis involved construction of a peristimulus time histogram (psth) and psf. Surface emg analysis involved signal averaging. Cumulative sums (cusums) were calculated for semg, psth, and psf data. Forty-five single motor units were identified. The average number of stimuli per unit was 201 ? 112. Characterisation of the response evoked by tms differed with the use of semg, psth, and psf cusums. The duration of the emg silence that follows the mep during voluntary contraction was longer in the psf than semg and psth. These findings highlight the importance of using both probability and frequency-based analysis when determining the duration of inhibitory events in peripheral recordings
Original languageEnglish
Pages (from-to)1002 - 1009
Number of pages8
JournalClinical Neurophysiology
Volume123
Issue number5
DOIs
Publication statusPublished - 2012

Cite this