Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity

Zimu Wu; Robyn L. Woods; Rory Wolfe; Elsdon Storey; Trevor T.J. Chong; Raj C Shah; Suzanne Orchard; John J. McNeil; Anne M. Murray; Joanne Ryan; the ASPREE Investigator Group

doi:10.1002/dad2.12180

Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity

Zimu Wu, Robyn L. Woods, Rory Wolfe, Elsdon Storey, Trevor T.J. Chong, Raj C Shah, Suzanne Orchard, John J. McNeil, Anne M. Murray, Joanne Ryan, the ASPREE Investigator Group

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9%) and memory (33.2%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.

Original language	English
Article number	e12180
Number of pages	12
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12180
Publication status	Published - 2 May 2021

Keywords

Cognitive function
Dementia
Longitudinal
Older adults
Prospective

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/dad2.12180Licence: CC BY

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Wu, Z., Woods, R. L., Wolfe, R., Storey, E., Chong, T. T. J., Shah, R. C., Orchard, S., McNeil, J. J., Murray, A. M., Ryan, J., & the ASPREE Investigator Group (2021). Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1), Article e12180. https://doi.org/10.1002/dad2.12180

@article{c5a0a228e0da4dc9b9dd59ffd45fecc9,

title = "Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity",

abstract = "Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9\%) and memory (33.2\%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.",

keywords = "Cognitive function, Dementia, Longitudinal, Older adults, Prospective",

author = "Zimu Wu and Woods, \{Robyn L.\} and Rory Wolfe and Elsdon Storey and Chong, \{Trevor T.J.\} and Shah, \{Raj C\} and Suzanne Orchard and McNeil, \{John J.\} and Murray, \{Anne M.\} and Joanne Ryan and \{the ASPREE Investigator Group\}",

note = "Funding Information: This work was supported by the National Institute on Aging and the National Cancer Institute at the National Institutes of Health (U01AG029824); the National Health and Medical Research Council (NHMRC) of Australia (334047 and 1127060); Monash University (Australia); and the Victorian Cancer Agency (Australia). Joanne Ryan is funded by an NHMRC Dementia Research Leader Fellowship (APP1135727). Zimu Wu is funded by a Research Training Program scholarship, awarded by Monash University and the Australian government. The funding bodies were not involved in study design; collection, analysis, and interpretation of the data; the writing of the manuscript; or in the decision to submit the article for publication. Funding Information: Anne M. Murray reports receiving consulting fees from Alkahest, Inc. and grants from the National Institute on Aging. Raj C. Shah reports grants for clinical research regarding dementia and Alzheimer{\textquoteright}s disease from the National Institutes of Health, the Centers for Medicare and Medicaid Services, the Department of Defense, and the Illinois Department of Public Health; being a non-compensated member of the Board of Directors of the Alzheimer{\textquoteright}s Association–Illinois Chapter; and being a site principal investigator or sub-investigator for clinical trials and research studies for which his institution (Rush University Medical Center) is sponsored (Amylyx Pharmaceuticals, Inc.; Eli Lilly \& Co., Inc.; Genentech, Inc.; Lundbeck, Inc.; Merck \& Co, Inc.; Navidea Biopharmaceuticals; Novartis Pharmaceuticals, Inc.; Roche Holdings AG; and Takeda Development Center Americas, Inc.). Robyn L. Woods, Rory Wolfe, Elsdon Storey, Trevor T. J. Chong, John J. McNeil, and Suzanne G. Orchard report no competing interests. Publisher Copyright: {\textcopyright} 2021 The Authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = may,

day = "2",

doi = "10.1002/dad2.12180",

language = "English",

volume = "13",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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Wu, Z , Woods, RL , Wolfe, R , Storey, E , Chong, TTJ, Shah, RC, Orchard, S , McNeil, JJ, Murray, AM, Ryan, J & the ASPREE Investigator Group 2021, 'Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 13, no. 1, e12180. https://doi.org/10.1002/dad2.12180

TY - JOUR

T1 - Trajectories of cognitive function in community-dwelling older adults

T2 - A longitudinal study of population heterogeneity

AU - Wu, Zimu

AU - Woods, Robyn L.

AU - Wolfe, Rory

AU - Storey, Elsdon

AU - Chong, Trevor T.J.

AU - Shah, Raj C

AU - Orchard, Suzanne

AU - McNeil, John J.

AU - Murray, Anne M.

AU - Ryan, Joanne

AU - the ASPREE Investigator Group

N1 - Funding Information: This work was supported by the National Institute on Aging and the National Cancer Institute at the National Institutes of Health (U01AG029824); the National Health and Medical Research Council (NHMRC) of Australia (334047 and 1127060); Monash University (Australia); and the Victorian Cancer Agency (Australia). Joanne Ryan is funded by an NHMRC Dementia Research Leader Fellowship (APP1135727). Zimu Wu is funded by a Research Training Program scholarship, awarded by Monash University and the Australian government. The funding bodies were not involved in study design; collection, analysis, and interpretation of the data; the writing of the manuscript; or in the decision to submit the article for publication. Funding Information: Anne M. Murray reports receiving consulting fees from Alkahest, Inc. and grants from the National Institute on Aging. Raj C. Shah reports grants for clinical research regarding dementia and Alzheimer’s disease from the National Institutes of Health, the Centers for Medicare and Medicaid Services, the Department of Defense, and the Illinois Department of Public Health; being a non-compensated member of the Board of Directors of the Alzheimer’s Association–Illinois Chapter; and being a site principal investigator or sub-investigator for clinical trials and research studies for which his institution (Rush University Medical Center) is sponsored (Amylyx Pharmaceuticals, Inc.; Eli Lilly & Co., Inc.; Genentech, Inc.; Lundbeck, Inc.; Merck & Co, Inc.; Navidea Biopharmaceuticals; Novartis Pharmaceuticals, Inc.; Roche Holdings AG; and Takeda Development Center Americas, Inc.). Robyn L. Woods, Rory Wolfe, Elsdon Storey, Trevor T. J. Chong, John J. McNeil, and Suzanne G. Orchard report no competing interests. Publisher Copyright: © 2021 The Authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/2

Y1 - 2021/5/2

N2 - Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9%) and memory (33.2%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.

AB - Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9%) and memory (33.2%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.

KW - Cognitive function

KW - Dementia

KW - Longitudinal

KW - Older adults

KW - Prospective

UR - http://www.scopus.com/inward/record.url?scp=85108248690&partnerID=8YFLogxK

U2 - 10.1002/dad2.12180

DO - 10.1002/dad2.12180

M3 - Article

AN - SCOPUS:85108248690

SN - 2352-8729

VL - 13

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

M1 - e12180

ER -

Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Comprehensive risk prediction models and presymptomatic biomarkers for dementia

ASPREE Completion Project

A randomised double-blind placebo-controlled trial of aspirin in primary prevention of CVD events or dementia in the aged ID: 334047

Cite this

Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Comprehensive risk prediction models and presymptomatic biomarkers for dementia

ASPREE Completion Project

A randomised double-blind placebo-controlled trial of aspirin in primary prevention of CVD events or dementia in the aged ID: 334047

Cite this