Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age

Gayan Bowatte, Caroline J. Lodge, Luke D. Knibbs, Adrian J. Lowe, Bircan Erbas, Martina Dennekamp, Guy B. Marks, Graham Giles, Stephen Morrison, Bruce Thompson, Paul S. Thomas, Jennie Hui, Jennifer L. Perret, Michael J. Abramson, Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage

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Abstract

Background: Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent. 

Objectives: We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes. 

Methods: The study sample comprised the proband 2002 laboratory study of the Tasmanian Longitudinal Health Study. Mean annual residential nitrogen dioxide (NO2) exposure was estimated for current residential addresses using a validated land-use regression model. Associations between TRAP exposure and allergic sensitization, lung function, current wheeze, and asthma (n = 1405) were investigated using regression models. 

Results: Increased mean annual NO2 exposure was associated with increased risk of atopy (adjusted odds ratio [aOR], 1.14; 95% CI, 1.02-1.28 per 1 interquartile range increase in NO2 [2.2 ppb]) and current wheeze (aOR, 1.14; 1.02-1.28). Similarly, living less than 200 m from a major road was associated with current wheeze (aOR, 1.38; 95% CI, 1.06-1.80) and atopy (aOR, 1.26; 95% CI, 0.99-1.62), and was also associated with having significantly lower prebronchodilator and postbronchodilator FEV1 and prebronchodilator forced expiratory flow at 25% to 75% of forced vital capacity. We found evidence of interactions between living less than 200 m from a major road and GSTT1 polymorphism for atopy, asthma, and atopic asthma. Overall, carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to TRAP. 

Conclusions: Even relatively low TRAP exposures confer an increased risk of adverse respiratory and allergic outcomes in genetically susceptible individuals.

Original languageEnglish
Pages (from-to)122-129
Number of pages9
JournalJournal of Allergy and Clinical Immunology
Volume139
Issue number1
DOIs
Publication statusPublished - Jan 2017

Keywords

  • Air pollution
  • Allergic sensitization
  • Asthma
  • Glutathione S-Transferase genes
  • Respiratory function

Cite this

Bowatte, Gayan ; Lodge, Caroline J. ; Knibbs, Luke D. ; Lowe, Adrian J. ; Erbas, Bircan ; Dennekamp, Martina ; Marks, Guy B. ; Giles, Graham ; Morrison, Stephen ; Thompson, Bruce ; Thomas, Paul S. ; Hui, Jennie ; Perret, Jennifer L. ; Abramson, Michael J. ; Walters, Haydn ; Matheson, Melanie C. ; Dharmage, Shyamali C. / Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age. In: Journal of Allergy and Clinical Immunology. 2017 ; Vol. 139, No. 1. pp. 122-129.
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title = "Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age",
abstract = "Background: Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent. Objectives: We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes. Methods: The study sample comprised the proband 2002 laboratory study of the Tasmanian Longitudinal Health Study. Mean annual residential nitrogen dioxide (NO2) exposure was estimated for current residential addresses using a validated land-use regression model. Associations between TRAP exposure and allergic sensitization, lung function, current wheeze, and asthma (n = 1405) were investigated using regression models. Results: Increased mean annual NO2 exposure was associated with increased risk of atopy (adjusted odds ratio [aOR], 1.14; 95{\%} CI, 1.02-1.28 per 1 interquartile range increase in NO2 [2.2 ppb]) and current wheeze (aOR, 1.14; 1.02-1.28). Similarly, living less than 200 m from a major road was associated with current wheeze (aOR, 1.38; 95{\%} CI, 1.06-1.80) and atopy (aOR, 1.26; 95{\%} CI, 0.99-1.62), and was also associated with having significantly lower prebronchodilator and postbronchodilator FEV1 and prebronchodilator forced expiratory flow at 25{\%} to 75{\%} of forced vital capacity. We found evidence of interactions between living less than 200 m from a major road and GSTT1 polymorphism for atopy, asthma, and atopic asthma. Overall, carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to TRAP. Conclusions: Even relatively low TRAP exposures confer an increased risk of adverse respiratory and allergic outcomes in genetically susceptible individuals.",
keywords = "Air pollution, Allergic sensitization, Asthma, Glutathione S-Transferase genes, Respiratory function",
author = "Gayan Bowatte and Lodge, {Caroline J.} and Knibbs, {Luke D.} and Lowe, {Adrian J.} and Bircan Erbas and Martina Dennekamp and Marks, {Guy B.} and Graham Giles and Stephen Morrison and Bruce Thompson and Thomas, {Paul S.} and Jennie Hui and Perret, {Jennifer L.} and Abramson, {Michael J.} and Haydn Walters and Matheson, {Melanie C.} and Dharmage, {Shyamali C.}",
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journal = "Journal of Allergy and Clinical Immunology",
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Bowatte, G, Lodge, CJ, Knibbs, LD, Lowe, AJ, Erbas, B, Dennekamp, M, Marks, GB, Giles, G, Morrison, S, Thompson, B, Thomas, PS, Hui, J, Perret, JL, Abramson, MJ, Walters, H, Matheson, MC & Dharmage, SC 2017, 'Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age', Journal of Allergy and Clinical Immunology, vol. 139, no. 1, pp. 122-129. https://doi.org/10.1016/j.jaci.2016.05.008

Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age. / Bowatte, Gayan; Lodge, Caroline J.; Knibbs, Luke D.; Lowe, Adrian J.; Erbas, Bircan; Dennekamp, Martina; Marks, Guy B.; Giles, Graham; Morrison, Stephen; Thompson, Bruce; Thomas, Paul S.; Hui, Jennie; Perret, Jennifer L.; Abramson, Michael J.; Walters, Haydn; Matheson, Melanie C.; Dharmage, Shyamali C.

In: Journal of Allergy and Clinical Immunology, Vol. 139, No. 1, 01.2017, p. 122-129.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Traffic-related air pollution exposure is associated with allergic sensitization, asthma, and poor lung function in middle age

AU - Bowatte, Gayan

AU - Lodge, Caroline J.

AU - Knibbs, Luke D.

AU - Lowe, Adrian J.

AU - Erbas, Bircan

AU - Dennekamp, Martina

AU - Marks, Guy B.

AU - Giles, Graham

AU - Morrison, Stephen

AU - Thompson, Bruce

AU - Thomas, Paul S.

AU - Hui, Jennie

AU - Perret, Jennifer L.

AU - Abramson, Michael J.

AU - Walters, Haydn

AU - Matheson, Melanie C.

AU - Dharmage, Shyamali C.

PY - 2017/1

Y1 - 2017/1

N2 - Background: Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent. Objectives: We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes. Methods: The study sample comprised the proband 2002 laboratory study of the Tasmanian Longitudinal Health Study. Mean annual residential nitrogen dioxide (NO2) exposure was estimated for current residential addresses using a validated land-use regression model. Associations between TRAP exposure and allergic sensitization, lung function, current wheeze, and asthma (n = 1405) were investigated using regression models. Results: Increased mean annual NO2 exposure was associated with increased risk of atopy (adjusted odds ratio [aOR], 1.14; 95% CI, 1.02-1.28 per 1 interquartile range increase in NO2 [2.2 ppb]) and current wheeze (aOR, 1.14; 1.02-1.28). Similarly, living less than 200 m from a major road was associated with current wheeze (aOR, 1.38; 95% CI, 1.06-1.80) and atopy (aOR, 1.26; 95% CI, 0.99-1.62), and was also associated with having significantly lower prebronchodilator and postbronchodilator FEV1 and prebronchodilator forced expiratory flow at 25% to 75% of forced vital capacity. We found evidence of interactions between living less than 200 m from a major road and GSTT1 polymorphism for atopy, asthma, and atopic asthma. Overall, carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to TRAP. Conclusions: Even relatively low TRAP exposures confer an increased risk of adverse respiratory and allergic outcomes in genetically susceptible individuals.

AB - Background: Traffic-related air pollution (TRAP) exposure is associated with allergic airway diseases and reduced lung function in children, but evidence concerning adults, especially in low-pollution settings, is scarce and inconsistent. Objectives: We sought to determine whether exposure to TRAP in middle age is associated with allergic sensitization, current asthma, and reduced lung function in adults, and whether these associations are modified by variants in Glutathione S-Transferase genes. Methods: The study sample comprised the proband 2002 laboratory study of the Tasmanian Longitudinal Health Study. Mean annual residential nitrogen dioxide (NO2) exposure was estimated for current residential addresses using a validated land-use regression model. Associations between TRAP exposure and allergic sensitization, lung function, current wheeze, and asthma (n = 1405) were investigated using regression models. Results: Increased mean annual NO2 exposure was associated with increased risk of atopy (adjusted odds ratio [aOR], 1.14; 95% CI, 1.02-1.28 per 1 interquartile range increase in NO2 [2.2 ppb]) and current wheeze (aOR, 1.14; 1.02-1.28). Similarly, living less than 200 m from a major road was associated with current wheeze (aOR, 1.38; 95% CI, 1.06-1.80) and atopy (aOR, 1.26; 95% CI, 0.99-1.62), and was also associated with having significantly lower prebronchodilator and postbronchodilator FEV1 and prebronchodilator forced expiratory flow at 25% to 75% of forced vital capacity. We found evidence of interactions between living less than 200 m from a major road and GSTT1 polymorphism for atopy, asthma, and atopic asthma. Overall, carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to TRAP. Conclusions: Even relatively low TRAP exposures confer an increased risk of adverse respiratory and allergic outcomes in genetically susceptible individuals.

KW - Air pollution

KW - Allergic sensitization

KW - Asthma

KW - Glutathione S-Transferase genes

KW - Respiratory function

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U2 - 10.1016/j.jaci.2016.05.008

DO - 10.1016/j.jaci.2016.05.008

M3 - Article

VL - 139

SP - 122

EP - 129

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

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