Tracking regional brain growth up to age 13 in children born term and very preterm

Deanne K. Thompson; Lillian G. Matthews; Bonnie Alexander; Katherine J. Lee; Claire E. Kelly; Chris L. Adamson; Rod W. Hunt; Jeanie L.Y. Cheong; Megan Spencer-Smith; Jeffrey J. Neil; Marc L. Seal; Terrie E. Inder; Lex W. Doyle; Peter J. Anderson

doi:10.1038/s41467-020-14334-9

Tracking regional brain growth up to age 13 in children born term and very preterm

Deanne K. Thompson, Lillian G. Matthews, Bonnie Alexander, Katherine J. Lee, Claire E. Kelly, Chris L. Adamson, Rod W. Hunt, Jeanie L.Y. Cheong, Megan Spencer-Smith, Jeffrey J. Neil, Marc L. Seal, Terrie E. Inder, Lex W. Doyle, Peter J. Anderson

Psychology

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Abstract

Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.

Original language	English
Article number	696
Number of pages	11
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-14334-9
Publication status	Published - 4 Feb 2020

Keywords

development of the nervous system
developmental biology
neurology
paediatric research

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10.1038/s41467-020-14334-9

298455249-oaFinal published version, 6.46 MB

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Thompson, D. K., Matthews, L. G., Alexander, B., Lee, K. J., Kelly, C. E., Adamson, C. L., Hunt, R. W., Cheong, J. L. Y., Spencer-Smith, M., Neil, J. J., Seal, M. L., Inder, T. E., Doyle, L. W., & Anderson, P. J. (2020). Tracking regional brain growth up to age 13 in children born term and very preterm. Nature Communications, 11(1), Article 696. https://doi.org/10.1038/s41467-020-14334-9

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abstract = "Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.",

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author = "Thompson, {Deanne K.} and Matthews, {Lillian G.} and Bonnie Alexander and Lee, {Katherine J.} and Kelly, {Claire E.} and Adamson, {Chris L.} and Hunt, {Rod W.} and Cheong, {Jeanie L.Y.} and Megan Spencer-Smith and Neil, {Jeffrey J.} and Seal, {Marc L.} and Inder, {Terrie E.} and Doyle, {Lex W.} and Anderson, {Peter J.}",

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AU - Adamson, Chris L.

AU - Hunt, Rod W.

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AU - Neil, Jeffrey J.

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AU - Doyle, Lex W.

AU - Anderson, Peter J.

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AB - Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.

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Tracking regional brain growth up to age 13 in children born term and very preterm

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Keywords

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Improving the long-term outcomes for preterm children

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Tracking regional brain growth up to age 13 in children born term and very preterm

Abstract

Keywords

Access to Document

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Improving the long-term outcomes for preterm children

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