TY - JOUR
T1 - Toxoplasma and plasmodium protein kinases: roles in invasion and host cell remodelling
AU - Lim, Daniel C
AU - Cooke, Brian M
AU - Doerig, Christian D
AU - Saeij, Jeroen PJ
PY - 2012
Y1 - 2012
N2 - Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).
AB - Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22154850
U2 - 10.1016/j.ijpara.2011.11.007
DO - 10.1016/j.ijpara.2011.11.007
M3 - Article
SN - 0020-7519
VL - 42
SP - 21
EP - 32
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 1
ER -