Towards the preparative and large-scale precision manufacture of virus-like particles

Leonard Keith Pattenden, Anton PJ Middelberg, Marcus Niebert, Daniel I Lipin

Research output: Contribution to journalArticleResearchpeer-review

159 Citations (Scopus)


Virus-like particles (VLPs) are of interest in vaccination, gene therapy and drug delivery, but their potential has yet to be fully realized. This is because existing laboratory processes, when scaled, do not easily give a compositionally and architecturally consistent product. Research suggests that new process routes might ultimately be based on chemical processing by self-assembly, involving the precision manufacture of precursor capsomeres followed by in vitro VLP self-assembly and scale-up to required levels. A synergistic interaction of biomolecular design and bioprocess engineering (i.e. biomolecular engineering) is required if these alternative process routes and, thus, the promise of new VLP products, are to be realized.
Original languageEnglish
Pages (from-to)523 - 529
Number of pages7
JournalTrends in Biotechnology
Issue number10
Publication statusPublished - 2005

Cite this