Towards high throughput screening for drug discovery in multi splitting and merging system using microvalves

Sagar N. Agnihotri, Mohammad Reza Raveshi, Rajneesh Bhardwaj, Adrian Neild

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

Abstract

Single-layer microvalves are biocompatible, simple, and can be used at high-speed. Here, by the integration of these microvalves with other droplet microfluidic manipulation methods, we unveil an easy technique to use for splitting and merging of microdroplets at multiple locations, which makes it ideal for closed channel microfluidic high throughput screening. The presented multi splitting and merging microfluidic system is capable of generating four different kinds of droplets using four T-junctions, split them selectively in different volumes at four junctions using microvalves and merge the same/different kind of split droplets in various concentrations using pillar induced merging method.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages56-57
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2020) - Virtual, United States of America
Duration: 4 Oct 20209 Oct 2020
Conference number: 24th
https://microtas2020.org (Website)

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2020)
Abbreviated titleMicroTAS 2020
Country/TerritoryUnited States of America
Period4/10/209/10/20
Internet address

Keywords

  • Droplet microfluidic
  • High throughput screening
  • Microvalves
  • Splitting and merging

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