Towards an active micropump-mixer for rapid anti-platelet drug screening in whole blood

Crispin Szydzik, Rose J. Brazilek, Farzan Akbaridoust, Charitha De Silva, Mitchell Moon, Ivan Marusic, Harshal H. Nandurkar, Justin R. Hamilton, Arnan Mitchell, Warwick S. Nesbitt

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

Abstract

This work reports on development and characterization of an on-chip microfluidic handling system for application in preclinical anti-platelet drug screening. A reciprocating elastomeric micropump/mixer design is presented for use with whole human blood, utilizing flexible structural and actuation properties to manage hemodynamics for an on-chip platelet thrombosis assay on fibrillar collagen. The hemocompatibility of the design is assessed across a range of operational configurations, demonstrating equivalent or superior performance to common microcapillary systems at a range of physiologically relevant shear conditions. Surprisingly efficient mixing phenomena are briefly investigated, validated using dyes within the molecular weight range of common antiplatelet therapies. Finally, a proof-of-concept preclinical application is explored, demonstrating that this prototype can act as a real-time assay of anti-platelet drug pharmacokinetics, compared to an equivalent microcapillary system.

Original languageEnglish
Title of host publicationSPIE Micro + Nano Materials, Devices, and Applications 2019
EditorsM. Cather Simpson, Saulius Juodkazis
PublisherSPIE - International Society for Optical Engineering
Number of pages3
ISBN (Electronic)9781510631427
DOIs
Publication statusPublished - 1 Jan 2019
EventSPIE Micro + Nano Materials, Devices, and Applications 2019 - Melbourne, Australia
Duration: 9 Dec 201912 Dec 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11201
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceSPIE Micro + Nano Materials, Devices, and Applications 2019
CountryAustralia
CityMelbourne
Period9/12/1912/12/19

Keywords

  • Automated fluid handling
  • Blood pump
  • Drug screening
  • Hemocompatible
  • Microfluidics
  • Microvalves

Cite this

Szydzik, C., Brazilek, R. J., Akbaridoust, F., De Silva, C., Moon, M., Marusic, I., Nandurkar, H. H., Hamilton, J. R., Mitchell, A., & Nesbitt, W. S. (2019). Towards an active micropump-mixer for rapid anti-platelet drug screening in whole blood. In M. C. Simpson, & S. Juodkazis (Eds.), SPIE Micro + Nano Materials, Devices, and Applications 2019 [1120116] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11201). SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.2541102