@inproceedings{78c64d57bcd34f1281c68df6c65d6165,
title = "Towards an active micropump-mixer for rapid anti-platelet drug screening in whole blood",
abstract = "This work reports on development and characterization of an on-chip microfluidic handling system for application in preclinical anti-platelet drug screening. A reciprocating elastomeric micropump/mixer design is presented for use with whole human blood, utilizing flexible structural and actuation properties to manage hemodynamics for an on-chip platelet thrombosis assay on fibrillar collagen. The hemocompatibility of the design is assessed across a range of operational configurations, demonstrating equivalent or superior performance to common microcapillary systems at a range of physiologically relevant shear conditions. Surprisingly efficient mixing phenomena are briefly investigated, validated using dyes within the molecular weight range of common antiplatelet therapies. Finally, a proof-of-concept preclinical application is explored, demonstrating that this prototype can act as a real-time assay of anti-platelet drug pharmacokinetics, compared to an equivalent microcapillary system.",
keywords = "Automated fluid handling, Blood pump, Drug screening, Hemocompatible, Microfluidics, Microvalves",
author = "Crispin Szydzik and Brazilek, {Rose J.} and Farzan Akbaridoust and {De Silva}, Charitha and Mitchell Moon and Ivan Marusic and Nandurkar, {Harshal H.} and Hamilton, {Justin R.} and Arnan Mitchell and Nesbitt, {Warwick S.}",
year = "2019",
month = jan,
day = "1",
doi = "10.1117/12.2541102",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE - International Society for Optical Engineering",
editor = "Simpson, {M. Cather} and Saulius Juodkazis",
booktitle = "SPIE Micro + Nano Materials, Devices, and Applications 2019",
note = "SPIE Micro + Nano Materials, Devices, and Applications 2019 ; Conference date: 09-12-2019 Through 12-12-2019",
}