Towards a structural understanding of the anti-ulcer and anti-gastritis drug bismuth subsalicylate

Philip Craig Andrews, Glen Berenger Deacon, Craig Macdonald Forsyth, Peter Courtney Junk, Ish Kumar, Melissa Maguire

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106 Citations (Scopus)

Abstract

The action of Pepto-Bismol arising from the structure and hydrolysis of bismuth subsalicylate (BSS) is not yet understood. Two bismuth oxosalicylate clusters, [Bi38O44(HSal)26(Me 2CO)16(H2O)2] (1) and [Bi 9O7(HSal)13(Me2CO)5] (2), have been characterized which provide structural insight into the nature of BSS. A Bi9O7 cluster forms the core of 2 and is found at the heart of 1 (see picture; core Bi atoms: green, core O atoms: red). (Figure Presented).

Original languageEnglish
Pages (from-to)5638-5642
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number34
DOIs
Publication statusPublished - 2 Sep 2006

Keywords

  • Bismuth
  • Bismuth oxide
  • Oxo ligands
  • Salicylate ligands
  • Solid-state structures

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