Agency work is one of the most rapidly growing forms of employment in leading economies over the past two decades, signifying a global shift towards non-standard flexible employment modes. The rapid growth of agency work has become one of the most notable global employment trends and is set to become a permanent feature of the modern workplace. The growth of agency employment raises a number of ethical challenges for governments and businesses. A key emerging challenge is to identify firm-level HRM strategies to effectively manage and protect agency employees. Based on an extensive review of the existing research on agency work, this article develops an organizational-level flexicurity model of HRM as a promising answer to effectively manage agency employees in responsible ways within the context of increasing employment flexibilization. This article also develops a research agenda, providing a platform to inform future research.