Towards a case definition for devil facial tumour disease: What is it?

Stephen B. Pyecroft; Anne Maree Pearse; Richmond Loh; Kate Swift; Kathy Belov; Nolan Fox; Erin Noonan; Dane Hayes; Alex Hyatt; Lingfa Wang; David Boyle; Jeff Church; Debra Middleton; Robert Moore

doi:10.1007/s10393-007-0126-0

Towards a case definition for devil facial tumour disease: What is it?

Stephen B. Pyecroft, Anne Maree Pearse, Richmond Loh, Kate Swift, Kathy Belov, Nolan Fox, Erin Noonan, Dane Hayes, Alex Hyatt, Lingfa Wang, David Boyle, Jeff Church, Debra Middleton, Robert Moore

Microbiology

Research output: Contribution to journal › Article › Research › peer-review

81 Citations (Scopus)

Abstract

In the mid 1990s an emerging disease characterised by the development of proliferative lesions around the face of Tasmanian devils (Sarcophilus harrisii) was observed. A multi-disciplinary approach was adopted to define the condition. Histopathological and transmission electron microscopic examination combined with immunohistochemistry help define Devil Facial Tumour Disease (DFTD) as a neoplastic condition of cells of neuroendocrine origin. Cytogenetic analysis of neoplastic tissue revealed it to be markedly different from normal devil tissue and having a consistent karyotype across all tumours examined. Combined with evidence for Major histocompatability (MHC) gene analysis there is significant evidence to confirm the tumour is a transmissible neoplasm.

Original language	English
Pages (from-to)	346-351
Number of pages	6
Journal	EcoHealth
Volume	4
Issue number	3
DOIs	https://doi.org/10.1007/s10393-007-0126-0
Publication status	Published - 1 Sept 2007

Keywords

Facial tumour
Karyotype
Neoplasm
Neuroendocrine
Sarcophilus harrisii
Tasmanian devil

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title = "Towards a case definition for devil facial tumour disease: What is it?",

abstract = "In the mid 1990s an emerging disease characterised by the development of proliferative lesions around the face of Tasmanian devils (Sarcophilus harrisii) was observed. A multi-disciplinary approach was adopted to define the condition. Histopathological and transmission electron microscopic examination combined with immunohistochemistry help define Devil Facial Tumour Disease (DFTD) as a neoplastic condition of cells of neuroendocrine origin. Cytogenetic analysis of neoplastic tissue revealed it to be markedly different from normal devil tissue and having a consistent karyotype across all tumours examined. Combined with evidence for Major histocompatability (MHC) gene analysis there is significant evidence to confirm the tumour is a transmissible neoplasm.",

keywords = "Facial tumour, Karyotype, Neoplasm, Neuroendocrine, Sarcophilus harrisii, Tasmanian devil",

author = "Pyecroft, \{Stephen B.\} and Pearse, \{Anne Maree\} and Richmond Loh and Kate Swift and Kathy Belov and Nolan Fox and Erin Noonan and Dane Hayes and Alex Hyatt and Lingfa Wang and David Boyle and Jeff Church and Debra Middleton and Robert Moore",

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T2 - What is it?

AU - Pyecroft, Stephen B.

AU - Pearse, Anne Maree

AU - Loh, Richmond

AU - Swift, Kate

AU - Belov, Kathy

AU - Fox, Nolan

AU - Noonan, Erin

AU - Hayes, Dane

AU - Hyatt, Alex

AU - Wang, Lingfa

AU - Boyle, David

AU - Church, Jeff

AU - Middleton, Debra

AU - Moore, Robert

PY - 2007/9/1

Y1 - 2007/9/1

N2 - In the mid 1990s an emerging disease characterised by the development of proliferative lesions around the face of Tasmanian devils (Sarcophilus harrisii) was observed. A multi-disciplinary approach was adopted to define the condition. Histopathological and transmission electron microscopic examination combined with immunohistochemistry help define Devil Facial Tumour Disease (DFTD) as a neoplastic condition of cells of neuroendocrine origin. Cytogenetic analysis of neoplastic tissue revealed it to be markedly different from normal devil tissue and having a consistent karyotype across all tumours examined. Combined with evidence for Major histocompatability (MHC) gene analysis there is significant evidence to confirm the tumour is a transmissible neoplasm.

AB - In the mid 1990s an emerging disease characterised by the development of proliferative lesions around the face of Tasmanian devils (Sarcophilus harrisii) was observed. A multi-disciplinary approach was adopted to define the condition. Histopathological and transmission electron microscopic examination combined with immunohistochemistry help define Devil Facial Tumour Disease (DFTD) as a neoplastic condition of cells of neuroendocrine origin. Cytogenetic analysis of neoplastic tissue revealed it to be markedly different from normal devil tissue and having a consistent karyotype across all tumours examined. Combined with evidence for Major histocompatability (MHC) gene analysis there is significant evidence to confirm the tumour is a transmissible neoplasm.

KW - Facial tumour

KW - Karyotype

KW - Neoplasm

KW - Neuroendocrine

KW - Sarcophilus harrisii

KW - Tasmanian devil

UR - https://www.scopus.com/pages/publications/35148823198

U2 - 10.1007/s10393-007-0126-0

DO - 10.1007/s10393-007-0126-0

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SN - 1612-9202

VL - 4

SP - 346

EP - 351

JO - EcoHealth

JF - EcoHealth

IS - 3

ER -

Towards a case definition for devil facial tumour disease: What is it?

Abstract

Keywords

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