Toward the design of LPEI containing block copolymers: Improved synthesis protocol, selective hydrolysis, and detailed characterization

Lutz Tauhardt, Kristian Kempe, Ulrich S. Schubert

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14 Citations (Scopus)


The synthesis of poly(2-ethyl-2-oxazoline)-b-linear poly(ethylenimine) (PEtOx-b-LPEI) copolymers by selective basic hydrolysis of PEtOx-b-poly(2-H-2- oxazoline) (PEtOx-b-PHOx) is described. For this purpose, an easy method for the preparation of the 2-H-2-oxazoline (HOx) monomer was developed. Based on the microwave-assisted polymerization kinetics for this monomer, PEtOx-b-PHOx copolymers were prepared. Subsequently, the block copolymers were selectively hydrolyzed to PEtOx-b-LPEI under basic conditions. The success of the polymerizations and subsequent post-polymerization reactions was demonstrated by 1H NMR spectroscopy and MALDI-TOF-MS investigations of the obtained polymers.

Original languageEnglish
Pages (from-to)4516-4523
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number21
Publication statusPublished - 1 Nov 2012
Externally publishedYes


  • block copolymer
  • cationic polymerization
  • linear poly(ethylenimine)
  • poly(2-H-2-oxazoline)
  • ring-opening polymerization

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