Toward preparative resolution of chiral alcohols by an organic chemical method

Nino Malic, Cornelis Moorhoff, Valerie Sage, Dilek Saylik, Ching Teoh, Janet Scott, Christopher Strauss

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    Abstract

    Asymmetric alcohols were resolved as 1-alpha-O-alkyl-2,3-unsaturated hexosides. After separation of diastereoisomers, the auxiliary and the enantiomeric alcohol were recovered by transglycosidation. Potential applications include resolution of labile secondary and tertiary alcohols, difficult by existing techniques, and enhancement of ees of chiral alcohols produced enzymatically or by synthetic catalytic methods.
    Original languageEnglish
    Pages (from-to)398 - 402
    Number of pages5
    JournalNew Journal of Chemistry
    Volume34
    Issue number3
    DOIs
    Publication statusPublished - 2010

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