Abstract
Objective: Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantial work remains to create accurate comprehensive models of complex cells.
Methods: We organized the 2015 Whole-Cell Modeling Summer School to teach WC modeling and evaluate the need for new WC modeling standards and software by recoding a recently published WC model in the Systems Biology Markup Language.
Results: Our analysis revealed several challenges to representing WC models using the current standards.
Conclusion: We, therefore, propose several new WC modeling standards, software, and databases. Significance: We anticipate that these new standards and software will enable more comprehensive models.
Original language | English |
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Article number | 7489010 |
Pages (from-to) | 2007-2014 |
Number of pages | 8 |
Journal | IEEE Transactions on Biomedical Engineering |
Volume | 63 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2016 |
Keywords
- Computational biology
- Education
- Simulation
- Standards
- Systems biology
- Whole-cell (WC) modeling