Toward colloid-based biosensors for SNP genotyping and personalised medicine applications

Angus P R Johnston, Gwendolyn A. Lawrie, Bronwyn J. Battersby, Simon R. Corrie, Matt Trau

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Therapeutic drugs can assist some patients, however, other individuals may exhibit no response. Furthermore, a drug that is normally considered to be safe can have toxic effects in a small proportion of the population, occasionally causing death. Many altered drug responses depend on the genetic constitution of the recipient [1-3]. The analysis of specific DNA markers within the genome of an individual [single nucleotide polymorphism (SNP) genotyping] could potentially identify subjects at risk in clinical trials and may enable clinicians to individualise medical therapy. The development of technology for personalised medicine relies on the ability to accurately and rapidly identify SNPs in genetic material. Some of the biotechnology tools for SNP identification are colloid-based biosensors, which are proving to possess several advantages over the traditional microarray format. Here, we survey the current technologies used for SNP genotyping and review colloid-based biosensors which are emerging as a higher throughput, potentially more accurate, technology.

Original languageEnglish
Pages (from-to)299-317
Number of pages19
JournalInternational Journal of Nanotechnology
Volume5
Issue number2-3
DOIs
Publication statusPublished - 1 Jan 2008
Externally publishedYes

Keywords

  • Colloids
  • Diagnostics
  • Flow cytometry
  • Genotyping
  • SNPs

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