Toward a Mechanical Mapping of the Arterial Tree: Challenges and Potential Solutions

R. L. Maurice, K. Y.H. Chen, D. Burgner, L. B. Daniels, L. Vaujois, Nikmah Salamia Idris, J. L. Bigras, Nagib Dahdah

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Cardiovascular disease (CVD) remains the main killer worldwide, despite major advances in healthcare and therapeutic measures. Much effort is invested in preventive care in order to improve health outcomes further. Vascular physiology modulation is a key element for early diagnosis and risk stratification.Our long-term objective is to facilitate identification of individuals at increased risk of CVD earlier in life. This would allow primary prevention, prior to the onset of clinical disease. We have documented an enhanced technique where we studied arterial stiffness, an independent predictor of CVD. Our method is able to detect functional changes prior to the onset of anatomical modification in youth. The aim of this work is to establish a longitudinal mechanical mapping of the arterial tree in healthy individuals.We report clinical data on the common carotid, abdominal aorta, and brachial arteries. These preliminary results will serve as a foundation for CVD research.

Original languageEnglish
Title of host publicationComputing and Visualization for Intravascular Imaging and Computer-Assisted Stenting
EditorsSimone Balocco, Maria A. Zuluaga, Guillaume Zahnd, Su-Lin Lee, Stefanie Demirci
Place of PublicationLondon UK
PublisherElsevier
Pages289-311
Number of pages23
ISBN (Electronic)9780128110195
ISBN (Print)9780128110188
DOIs
Publication statusPublished - 2017

Keywords

  • Abdominal aorta
  • Arterial stiffness
  • Arterial tree
  • Brachial artery
  • Cardiovascular disease
  • Common carotid artery
  • Imaging-based biomarker (ImBioMark)
  • Ultrasound elastography

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