Total synthesis of diversified 1,2-disubstituted benzimidazoles with green approach at room temperature

Yeong Keng Yoon; Mohamed Ashraf Ali; Ang Chee Wei; Tan Soo Choon; Lim Wan Leng; Oo Chuan Wei

doi:10.2174/157017861110141117150010

Total synthesis of diversified 1,2-disubstituted benzimidazoles with green approach at room temperature

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Lim Wan Leng, Oo Chuan Wei

Research output: Contribution to journal › Article › Research › peer-review

Abstract

A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are easily recyclable, the method presented is very suitable for scale-up production. Furthermore, products were obtained in high yield and easily isolated making this method very practical and attractive.

Original language	English
Pages (from-to)	785-789
Number of pages	5
Journal	Letters in Organic Chemistry
Volume	11
Issue number	10
DOIs	https://doi.org/10.2174/157017861110141117150010
Publication status	Published - Dec 2014
Externally published	Yes

Keywords

Benzimidazoles
Cycloaddition
Green chemistry
Reduction
Sodium bisulfite
Total synthesis

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10.2174/157017861110141117150010

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abstract = "A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are easily recyclable, the method presented is very suitable for scale-up production. Furthermore, products were obtained in high yield and easily isolated making this method very practical and attractive.",

keywords = "Benzimidazoles, Cycloaddition, Green chemistry, Reduction, Sodium bisulfite, Total synthesis",

author = "Yoon, {Yeong Keng} and Ali, {Mohamed Ashraf} and Wei, {Ang Chee} and Choon, {Tan Soo} and Leng, {Lim Wan} and Wei, {Oo Chuan}",

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AU - Yoon, Yeong Keng

AU - Ali, Mohamed Ashraf

AU - Wei, Ang Chee

AU - Choon, Tan Soo

AU - Leng, Lim Wan

AU - Wei, Oo Chuan

PY - 2014/12

Y1 - 2014/12

N2 - A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are easily recyclable, the method presented is very suitable for scale-up production. Furthermore, products were obtained in high yield and easily isolated making this method very practical and attractive.

AB - A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are easily recyclable, the method presented is very suitable for scale-up production. Furthermore, products were obtained in high yield and easily isolated making this method very practical and attractive.

KW - Benzimidazoles

KW - Cycloaddition

KW - Green chemistry

KW - Reduction

KW - Sodium bisulfite

KW - Total synthesis

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SN - 1570-1786

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ER -

Total synthesis of diversified 1,2-disubstituted benzimidazoles with green approach at room temperature

Abstract

Keywords

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