Total synthesis of diversified 1,2-disubstituted benzimidazoles with green approach at room temperature

Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Lim Wan Leng, Oo Chuan Wei

Research output: Contribution to journalArticleResearchpeer-review


A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are easily recyclable, the method presented is very suitable for scale-up production. Furthermore, products were obtained in high yield and easily isolated making this method very practical and attractive.

Original languageEnglish
Pages (from-to)785-789
Number of pages5
JournalLetters in Organic Chemistry
Issue number10
Publication statusPublished - Dec 2014
Externally publishedYes


  • Benzimidazoles
  • Cycloaddition
  • Green chemistry
  • Reduction
  • Sodium bisulfite
  • Total synthesis

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