Total energy expenditure measured using doubly labeled water compared with estimated energy requirements in older adults (≥65 y)

analysis of primary data

Judi Porter, Kay Nguo, Jorja Collins, Nicole Kellow, Catherine Huggins, Simone Gibson, Zoe E. Davidson, Dale Schoeller, Ross L. Prentice, Marian L. Neuhouser, Linda Snetselaar, Helen Truby

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND: Contemporary energy expenditure data are crucial to inform and guide nutrition policy in older adults to optimize nutrition and health.

OBJECTIVE: The aim was to determine the optimal method of estimating total energy expenditure (TEE) in adults (aged ≥65 y) through 1) establishing which published predictive equations have the closest agreement between measured resting metabolic rate (RMR) and predicted RMR and 2) utilizing the RMR equations with the best agreement to predict TEE against the reference method of doubly labeled water (DLW).

METHODS: A database consisting of international participant-level TEE data from DLW studies was developed to enable comparison with energy requirements estimated by 17 commonly used predictive equations. This database included 31 studies comprising 988 participant-level RMR data and 1488 participant-level TEE data. Mean physical activity level (PAL) was determined for men (PAL=1.69, n=320) and women (PAL=1.66, n=668). Bland-Altman plots assessed agreement of measured RMR and TEE with predicted RMR and TEE in adults aged ≥65 y, and subgroups of 65-79 y and ≥80 y. Linear regression assessed proportional bias.

RESULTS: The Ikeda, Livingston, and Mifflin equations most closely agreed with measured RMR and TEE in all adults aged ≥65 y and in the 65-79 y and ≥80 y subgroups. In adults aged ≥65 y, the Ikeda and Livingston equations overestimated TEE by a mean±SD of 175±1362 kJ/d and 86±1344 kJ/d, respectively. The Mifflin equation underestimated TEE by a mean±SD of 24±1401 kJ/d. Proportional bias was present as energy expenditure increased.

CONCLUSIONS: The Ikeda, Livingston, or Mifflin equations are recommended for estimating energy requirements of older adults. Future research should focus on developing predictive equations to meet the requirements of the older population with consideration given to body composition and functional measures.
Original languageEnglish
Number of pages9
JournalThe American journal of clinical nutrition
DOIs
Publication statusAccepted/In press - 28 Aug 2019

Cite this

@article{b5c552bc3c7c4cfb93dedf55fea49976,
title = "Total energy expenditure measured using doubly labeled water compared with estimated energy requirements in older adults (≥65 y): analysis of primary data",
abstract = "BACKGROUND: Contemporary energy expenditure data are crucial to inform and guide nutrition policy in older adults to optimize nutrition and health.OBJECTIVE: The aim was to determine the optimal method of estimating total energy expenditure (TEE) in adults (aged ≥65 y) through 1) establishing which published predictive equations have the closest agreement between measured resting metabolic rate (RMR) and predicted RMR and 2) utilizing the RMR equations with the best agreement to predict TEE against the reference method of doubly labeled water (DLW).METHODS: A database consisting of international participant-level TEE data from DLW studies was developed to enable comparison with energy requirements estimated by 17 commonly used predictive equations. This database included 31 studies comprising 988 participant-level RMR data and 1488 participant-level TEE data. Mean physical activity level (PAL) was determined for men (PAL=1.69, n=320) and women (PAL=1.66, n=668). Bland-Altman plots assessed agreement of measured RMR and TEE with predicted RMR and TEE in adults aged ≥65 y, and subgroups of 65-79 y and ≥80 y. Linear regression assessed proportional bias.RESULTS: The Ikeda, Livingston, and Mifflin equations most closely agreed with measured RMR and TEE in all adults aged ≥65 y and in the 65-79 y and ≥80 y subgroups. In adults aged ≥65 y, the Ikeda and Livingston equations overestimated TEE by a mean±SD of 175±1362 kJ/d and 86±1344 kJ/d, respectively. The Mifflin equation underestimated TEE by a mean±SD of 24±1401 kJ/d. Proportional bias was present as energy expenditure increased.CONCLUSIONS: The Ikeda, Livingston, or Mifflin equations are recommended for estimating energy requirements of older adults. Future research should focus on developing predictive equations to meet the requirements of the older population with consideration given to body composition and functional measures.",
author = "Judi Porter and Kay Nguo and Jorja Collins and Nicole Kellow and Catherine Huggins and Simone Gibson and Davidson, {Zoe E.} and Dale Schoeller and Prentice, {Ross L.} and Neuhouser, {Marian L.} and Linda Snetselaar and Helen Truby",
year = "2019",
month = "8",
day = "28",
doi = "10.1093/ajcn/nqz200",
language = "English",
journal = "The American journal of clinical nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",

}

TY - JOUR

T1 - Total energy expenditure measured using doubly labeled water compared with estimated energy requirements in older adults (≥65 y)

T2 - analysis of primary data

AU - Porter, Judi

AU - Nguo, Kay

AU - Collins, Jorja

AU - Kellow, Nicole

AU - Huggins, Catherine

AU - Gibson, Simone

AU - Davidson, Zoe E.

AU - Schoeller, Dale

AU - Prentice, Ross L.

AU - Neuhouser, Marian L.

AU - Snetselaar, Linda

AU - Truby, Helen

PY - 2019/8/28

Y1 - 2019/8/28

N2 - BACKGROUND: Contemporary energy expenditure data are crucial to inform and guide nutrition policy in older adults to optimize nutrition and health.OBJECTIVE: The aim was to determine the optimal method of estimating total energy expenditure (TEE) in adults (aged ≥65 y) through 1) establishing which published predictive equations have the closest agreement between measured resting metabolic rate (RMR) and predicted RMR and 2) utilizing the RMR equations with the best agreement to predict TEE against the reference method of doubly labeled water (DLW).METHODS: A database consisting of international participant-level TEE data from DLW studies was developed to enable comparison with energy requirements estimated by 17 commonly used predictive equations. This database included 31 studies comprising 988 participant-level RMR data and 1488 participant-level TEE data. Mean physical activity level (PAL) was determined for men (PAL=1.69, n=320) and women (PAL=1.66, n=668). Bland-Altman plots assessed agreement of measured RMR and TEE with predicted RMR and TEE in adults aged ≥65 y, and subgroups of 65-79 y and ≥80 y. Linear regression assessed proportional bias.RESULTS: The Ikeda, Livingston, and Mifflin equations most closely agreed with measured RMR and TEE in all adults aged ≥65 y and in the 65-79 y and ≥80 y subgroups. In adults aged ≥65 y, the Ikeda and Livingston equations overestimated TEE by a mean±SD of 175±1362 kJ/d and 86±1344 kJ/d, respectively. The Mifflin equation underestimated TEE by a mean±SD of 24±1401 kJ/d. Proportional bias was present as energy expenditure increased.CONCLUSIONS: The Ikeda, Livingston, or Mifflin equations are recommended for estimating energy requirements of older adults. Future research should focus on developing predictive equations to meet the requirements of the older population with consideration given to body composition and functional measures.

AB - BACKGROUND: Contemporary energy expenditure data are crucial to inform and guide nutrition policy in older adults to optimize nutrition and health.OBJECTIVE: The aim was to determine the optimal method of estimating total energy expenditure (TEE) in adults (aged ≥65 y) through 1) establishing which published predictive equations have the closest agreement between measured resting metabolic rate (RMR) and predicted RMR and 2) utilizing the RMR equations with the best agreement to predict TEE against the reference method of doubly labeled water (DLW).METHODS: A database consisting of international participant-level TEE data from DLW studies was developed to enable comparison with energy requirements estimated by 17 commonly used predictive equations. This database included 31 studies comprising 988 participant-level RMR data and 1488 participant-level TEE data. Mean physical activity level (PAL) was determined for men (PAL=1.69, n=320) and women (PAL=1.66, n=668). Bland-Altman plots assessed agreement of measured RMR and TEE with predicted RMR and TEE in adults aged ≥65 y, and subgroups of 65-79 y and ≥80 y. Linear regression assessed proportional bias.RESULTS: The Ikeda, Livingston, and Mifflin equations most closely agreed with measured RMR and TEE in all adults aged ≥65 y and in the 65-79 y and ≥80 y subgroups. In adults aged ≥65 y, the Ikeda and Livingston equations overestimated TEE by a mean±SD of 175±1362 kJ/d and 86±1344 kJ/d, respectively. The Mifflin equation underestimated TEE by a mean±SD of 24±1401 kJ/d. Proportional bias was present as energy expenditure increased.CONCLUSIONS: The Ikeda, Livingston, or Mifflin equations are recommended for estimating energy requirements of older adults. Future research should focus on developing predictive equations to meet the requirements of the older population with consideration given to body composition and functional measures.

U2 - 10.1093/ajcn/nqz200

DO - 10.1093/ajcn/nqz200

M3 - Article

JO - The American journal of clinical nutrition

JF - The American journal of clinical nutrition

SN - 0002-9165

ER -