Projects per year
Background:Ethanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent.Methods:Using a case–control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment. Furthermore, we delineated the relationships for beverage-specific intakes of beer, red wine, white wine and spirits.Results:The study included 1282 APC cases and 951 controls. Beer intake frequency of ⩾5 days per week was associated with increased risk compared with no beer intake (odds ratio=1.66, 95% confidence interval: 1.12–2.48) whereas wine was protective at all frequencies of consumption compared with those with no wine intake. For every 10 g per week ethanol intake from beer increase, the odds of advanced PC rose by 3% (OR=1.03, 95% CI: 1.02–1.05). No such increased risk was observed for red or white wine while a marginal dose–response relationship was found for spirits (OR=1.03, 95% CI: 0.99–1.07).Conclusions:Heavy beer and possibly spirits consumption is associated with increased risk while no dose–response relationship was found for red or white wine. Wine drinkers at all frequencies have a decreased risk of APC compared with those who did not drink wine.Prostate Cancer and Prostatic Diseases advance online publication, 18 April 2017; doi:10.1038/pcan.2017.12.
|Number of pages||6|
|Journal||Prostate Cancer and Prostatic Diseases|
|Publication status||Published - 18 Apr 2017|
- cancer epidemiology
- prostate cancer
- 1 Finished
A case control study of risk factors for aggressive prostate cancer
Giles, G., Bolton, D. M., Sim, M., Millar, J., Severi, G. & Benke, G.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/10 → 31/12/14