Total and beverage-specific alcohol intake and the risk of aggressive prostate cancer: a case–control study

N.P. Papa, R. J. MacInnis, Harindra Jayasekara, DR English, Damien Bolton, ID Davis, N. Lawrentschuk, JL Millar, J. Pedersen, G Severi, MC Southey, JL Hopper, GG Giles

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Abstract

Background:Ethanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent.Methods:Using a case–control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment. Furthermore, we delineated the relationships for beverage-specific intakes of beer, red wine, white wine and spirits.Results:The study included 1282 APC cases and 951 controls. Beer intake frequency of ⩾5 days per week was associated with increased risk compared with no beer intake (odds ratio=1.66, 95% confidence interval: 1.12–2.48) whereas wine was protective at all frequencies of consumption compared with those with no wine intake. For every 10 g per week ethanol intake from beer increase, the odds of advanced PC rose by 3% (OR=1.03, 95% CI: 1.02–1.05). No such increased risk was observed for red or white wine while a marginal dose–response relationship was found for spirits (OR=1.03, 95% CI: 0.99–1.07).Conclusions:Heavy beer and possibly spirits consumption is associated with increased risk while no dose–response relationship was found for red or white wine. Wine drinkers at all frequencies have a decreased risk of APC compared with those who did not drink wine.Prostate Cancer and Prostatic Diseases advance online publication, 18 April 2017; doi:10.1038/pcan.2017.12.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume20
DOIs
Publication statusPublished - 18 Apr 2017

Keywords

  • cancer epidemiology
  • prostate cancer

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