Topographical binding to mucosa-exposed cancer cells: pollen-mimetic porous microspheres with tunable pore sizes

Jiantao Feng, Ling Lin, Peipei Chen, Wenda Hua, Quanmei Sun, Zhuo Ao, Dongsheng Liu, Lei Jiang, Shutao Wang, Dong Han

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Mucoadhesives have been perceived as an effective approach for targeting the mucosa-associated diseases, which relied on the adhesive molecules to enhance the specificity. Here, topographical binding is proposed based on the fabrication of surface pore size tunable pollen-mimetic microspheres with phase separation and electrospray technology. We proved that microspheres with large-pores (pore size of 1005 ± 448 nm) were the excellent potential candidate for the mucoadhesives, as they not only possessed better adhesion ability, but also could topographically bind cervical cancer cells. Our methods of topographical binding offered a new way of designing the mucoadhesives for treating the mucosa-associated diseases.

Original languageEnglish
Pages (from-to)8961-8967
Number of pages7
JournalACS Applied Materials & Interfaces
Volume7
Issue number17
DOIs
Publication statusPublished - 6 May 2015
Externally publishedYes

Keywords

  • adhesive
  • cancer cell
  • microsphere
  • mucosa
  • topographical binding

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