Topiramate use in obese patients with binge eating disorder: An open study

Jose C. Appolinario, Leonardo F. Fontenelle, Marcelo Papelbaum, João R. Bueno, Walmir Coutinho

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Objective: To assess topiramate's efficacy and tolerability in a group of obese binge eaters with no neuropsychiatric comorbidity. Method: We consecutively selected 8 obese patients with binge eating disorder (BED) and no medical or psychiatric comorbidity from individuals seeking treatment for obesity. Treatment with topiramate at 150 mg daily was administered over a 16-week period. To assesss outcome, we employed the days with binge episodes per week (DBE), the Binge Eating Scale (BES), the Beck Depression Inventory (BDI), and body weight evaluation. Results: Of the 6 patients who completed the trial, all showed reduced binge eating. Four patients presented a total remission, and 2 had a marked reduction in binge eating frequency. The mean DBE decreased significantly from 4.3 to 1.1 (P = 0.03), as did the BES scores, which fell from 31.8 to 15.3 (P= 0.04). Moreover, there was a statistically significant weight loss (mean 4.1 kg, P = 0.04). The most frequent side effects were paresthesias, fatigue, and somnolence. Conclusion: Topiramate may be an effective and well-tolerated agent in the treatment of BED in obese patients.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalCanadian Journal of Psychiatry
Issue number3
Publication statusPublished - 1 Jan 2002
Externally publishedYes


  • BED
  • Binge eating disorder
  • Eating disorder
  • Obesity
  • Topiramate

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